Essentials of Biostatistics for Physicians, Nurses, and Clinicians

A fundamental and straightforward guide to using and
understanding statistical concepts in medical research

Designed specifically for healthcare practitioners who need to
understand basic biostatistics but do not have much time to spare,
The Essentials of Biostatistics for Physicians, Nurses and
Clinicians presents important statistical methods used in
today's biomedical research and provides insight on their
appropriate application. Rather than provide detailed mathematics
for each of these methods, the book emphasizes what healthcare
practitioners need to know to interpret and incorporate the latest
biomedical research into their practices.

The author draws from his own experience developing and teaching
biostatistics courses for physicians and nurses, offering a
presentation that is non-technical and accessible. The book begins
with a basic introduction to the relationship between biostatistics
and medical research, asking the question "why study statistics?,"
while also exploring the significance of statisitcal methods in
medical literature and clinical trials research. Subsequent
chapters explore key topics, including:

• Correlation, regression, and logistic regression

• Diagnostics

• Estimating means and proportions

• Normal distribution and the central limit theorem

• Sampling from populations

• Contingency tables

• Meta-analysis

• Nonparametric methods

• Survival analysis

Throughout the book, statistical methods that are often utilized
in biomedical research are outlined, including repeated measures
analysis of variance, hazard ratios, contingency tables, log rank
tests, bioequivalence, cross-over designs, selection bias, and
group sequential methods. Exercise sets at the end of each chapter
allow readers to test their comprehension of the presented concepts
and techniques.

The Essentials of Biostatistics for Physicians, Nurses, and
Clinicians is an excellent reference for doctors, nurses, and
other practicing clinicians in the fields of medicine, public
health, pharmacy, and the life sciences who need to understand and
apply statistical methods in their everyday work. It also serves as
a suitable supplement for courses on biostatistics at the
upper-undergraduate and graduate levels.

Auteur
Michael R. Chernick, PhD, is Manager of Biostatistical Services at Lankenau Institute for Medical Research, where he conducts statistical design and analysis for pharmaceutical research. He has more than thirty years of experience in the application of statistical methods to such areas as medicine, energy, engineering, insurance, and pharmaceuticals. Dr. Chernick is the author of Bootstrap Methods: A Guide for Practitioners and Researchers, Second Edition, and the coauthor of Introductory Biostatistics for the Health Sciences: Modern Applications Including Bootstrap, both published by Wiley.

Résumé
A fundamental and straightforward guide to using and understanding statistical concepts in medical research

Designed specifically for healthcare practitioners who need to understand basic biostatistics but do not have much time to spare, The Essentials of Biostatistics for Physicians, Nurses and Clinicians presents important statistical methods used in today's biomedical research and provides insight on their appropriate application. Rather than provide detailed mathematics for each of these methods, the book emphasizes what healthcare practitioners need to know to interpret and incorporate the latest biomedical research into their practices.

The author draws from his own experience developing and teaching biostatistics courses for physicians and nurses, offering a presentation that is non-technical and accessible. The book begins with a basic introduction to the relationship between biostatistics and medical research, asking the question "why study statistics?," while also exploring the significance of statisitcal methods in medical literature and clinical trials research. Subsequent chapters explore key topics, including:

• Correlation, regression, and logistic regression
• Diagnostics
• Estimating means and proportions
• Normal distribution and the central limit theorem
• Sampling from populations
• Contingency tables
• Meta-analysis
• Nonparametric methods
• Survival analysis
  Throughout the book, statistical methods that are often utilized in biomedical research are outlined, including repeated measures analysis of variance, hazard ratios, contingency tables, log rank tests, bioequivalence, cross-over designs, selection bias, and group sequential methods. Exercise sets at the end of each chapter allow readers to test their comprehension of the presented concepts and techniques.

The Essentials of Biostatistics for Physicians, Nurses, and Clinicians is an excellent reference for doctors, nurses, and other practicing clinicians in the fields of medicine, public health, pharmacy, and the life sciences who need to understand and apply statistical methods in their everyday work. It also serves as a suitable supplement for courses on biostatistics at the upper-undergraduate and graduate levels.

Contenu
Preface ix 1. The What, Why, and How of Biostatistics in Medical Research 1

1.1 Defi nition of Statistics and Biostatistics, 1

1.2 Why Study Statistics?, 3

1.3 The Medical Literature, 9

1.4 Medical Research Studies, 11

1.4.1 Cross-sectional studies including surveys, 11

1.4.2 Retrospective studies, 12

1.4.3 Prospective studies other than clinical trials, 12

1.4.4 Controlled clinical trials, 12

1.4.5 Conclusions, 13

1.5 Exercises, 14

2. Sampling from Populations 15

2.1 Definitions of Populations and Samples, 17

2.2 Simple Random Sampling, 18

2.3 Selecting Simple Random Samples, 19

2.4 Other Sampling Methods, 27

2.5 Generating Bootstrap Samples, 28

2.6 Exercises, 32

3. Graphics and Summary Statistics 34

3.1 Continuous and Discrete Data, 34

3.2 Categorical Data, 35

3.3 Frequency Histograms, 35

3.4 Stem-and-Leaf Diagrams, 38

3.5 Box Plots, 39

3.6 Bar and Pie Charts, 39

3.7 Measures of the Center of a Distribution, 42

3.8 Measures of Dispersion, 46

3.9 Exercises, 50

4. Normal Distribution and Related Properties 51

4.1 Averages and the Central Limit Theorem, 51

4.2 Standard Error of the Mean, 53

4.3 Student's t-Distribution, 53

4.4 Exercises, 55

5. Estimating Means and Proportions 58

5.1 The Binomial and Poisson Distributions, 58

5.2 Point Estimates, 59

5.3 Confi dence Intervals, 62

5.4 Sample Size Determination, 65

5.5 Bootstrap Principle and Bootstrap Confidence Intervals, 66

5.6 Exercises, 69

6. Hypothesis Testing 72

6.1 Type I and Type II Errors, 73

6.2 One-Tailed and Two-Tailed Tests, 74

6.3 P-Values, 74

6.4 Comparing Means from Two Independent Samples: Two-Sample t-Test, 75

6.5 Paired t-Test, 76

6.6 Testing a Single Binomial Proportion, 78

6.7 Relationship Between Confi dence Intervals and Hypothesis Tests, 79

6.8 Sample Size Determination, 80

6.9 Bootstrap Tests, 81

6.10 Medical Diagnosis: Sensitivity and Specificity, 82

6.11 Special Tests in Clinical Research, 83

6.11.1 Superiority tests, 84

6.11.2 Equivalence and bioequivalence, 84

6.11.3 Noninferiority tests, 86

6.12 Repeated Measures Analysis of Variance and Longitudinal Data Analysis, 86

6.13 Meta-Analysis, 88

6.14 Exercises, 92

7. Correlation, Regression, and Logistic Regression 95

7.1 Relationship Between Two Variables and the Scatter Plot, 96

7.2 Pearson's Correlation, 99

7.3 Simple Linear Regression and Least Squares Estimation, 101

7.4 Sensitivity to Outliers and Robust Regression, 104

7.5 Multiple Regression, 111

7.6 Logistic Reg…