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Pharmaceutical Powder Compaction Technology

  • Livre Relié
  • 358 Nombre de pages
"Revised to reflect modern pharmaceutical compacting techniques, this Second Edition guides pharmaceutical engineers, formulation ... Lire la suite
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Description

"Revised to reflect modern pharmaceutical compacting techniques, this Second Edition guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application. Compaction of powder constituents both active ingredient and excipients is examined to ensure consistent and reproducible disintegration and dispersion profiles. This unique reference covers: the physical structure of pharmaceutical compacts bonding phenomena that occur during powder compaction compression mechanisms of pharmaceutical particles theories and basic principles of powder compaction New topics include: compaction data analysis techniques the migration of powder constituents into commercialmanufacture instrumentation for compaction compaction functionality testing, which is likely to become a USP requirement design space for compaction metrics required for scalability in tablet compression interactive compaction and preformulation databasefor commonly used excipients"--Provided by publisher.

Résumé

Compaction of powder constituentsboth active ingredient and excipientsis examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application.

This unique reference covers:

  • The physical structure of pharmaceutical compacts
  • Bonding phenomena that occur during powder compaction
  • Compression mechanisms of pharmaceutical particles
  • Theories and basic principles of powder compaction

New topics include:

  • Compaction data analysis techniques
  • The migration of powder constituents into commercial manufacture
  • Instrumentation for compaction
  • Compaction functionality testing, which is likely to become a USP requirement
  • Design space for compaction
  • Metrics required for scalability in tablet compression
  • Interactive compaction and preformulation database for commonly used excipients


Contenu

THEORY OF COMPACTION
Intermolecular Bonding Forces: where materials and process come together
Graham Buckton
COMPACTION DATA ANALYSIS TECHNIQUES
Viscoelastic Models
Susan K. Lum
Application of Percolation Theory and Fractal Geometry to Tablet Compaction
Hans Leuenberger, Maxim Puchkov, Ruth Leu-Marseiler, Jean-Daniel Bonny, Michael N. Leuenberger
Post Compaction Data Analysis Techniques
Gary Bubb
INTRUMENTATION AND EQUIPMENT IN COMPACTION
Tablet Press Instrumentation in the Research and Development Environment
Gary Bubb
Advanced Compaction Research Equipment: Compaction Simulators
Colleen Ruegger, Metin Çelik
Compactability Functionality Test
Eay Okutgen
ROLE OF COMPACTION IN THE FORMULATION AND PROCESS DEVELOPMENT OF TABLETTING
Compaction Properties of Directly Compressible Materials
Gerad K. Bolhuis, Hans de Waard
Lubrication Issues in Direct Compaction
Gerad K. Bolhuis, Arne W. Hölzer
Crystal Engineering and Particle Design for the Powder Compaction Process
Anant Paradka, Peter York
Compaction of Combination Products
Carl T. Allenspach, Erika A. Zannou
Quality by Design and Compression
Chris Balducci, Rosario LoBrutto, Alan Royce, James Cheney, Dong Xiang, Olivia Darmuzey, Hedinn Valthorsson
Expert Systems and Their Use in Pharmaceutical Applications
Metin Çelik
Press-To-Press Scalability and Transitioning Factors
Gary Bubb

Détails sur le produit

Titre: Pharmaceutical Powder Compaction Technology
Sous-titre: 2nd Edition
Éditeur:
Code EAN: 9781420089172
ISBN: 978-1-4200-8917-2
Format: Livre Relié
Editeur: Taylor and Francis
Genre: Branches
nombre de pages: 358
Poids: 862g
Taille: H254mm x B178mm
Année: 2011
Auflage: 2. A.