Genomics and Personalized Medicine

Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence - their genome - against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is
limitless.

Informationen zum Autor Michael Snyder, PhD, is the Stanford Ascherman Professor, Chair of the Department of Genetics, and Director of the Center of Genomics and Personalized Medicine at Stanford University. His laboratory has produced many fundamental technologies for characterizing the human genome and other "-omes," including many pivotal discoveries about our DNA. In 2012 he used his own genome sequence to predict and help diagnose his own metabolic disorder, a storythat received international news attention and shined a light on the promise of genomics. Snyder a co-founder of several successful biotechnology companies, including Personalis, Protometrix (now part of Life Technologies), Affomix (now part of Illumina), and Exelixis. He is regarded as a pioneer in bringing Big Datainto medicine. Klappentext Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence - their genome - against known elements of Big Data, elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. Zusammenfassung In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics! the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics! part of a larger movement toward personalized medicine! is poised to revolutionize health care. By cross-referencing an individual's genetic sequence - their genome - against known elements of "Big Data!" elements of genomics are already being incorporated on a widespread basis! including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside! the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms! consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs. Inhaltsverzeichnis Acknowledgements; Introduction; 1: Personalized Medicine; What is personalized medicine?; What personal factors impact your health?; 2: Genome Fundamentals; What is DNA?; What is a genome?; What does the genome do?; How does one person's genome differ from another person's genome?; How do genomes of men and women differ?; How is the genome decoded?; 3: An Introduction to Cancer Genetics; What is cancer and how does it arise?; How do the BRCA1 and BRCA2 genes cause cancer?; What are examples of other genes implicated in cancer?; How does genetic information help us treat cancer?; 4: Genomics and Cancer Treatment; What has been learned from genome sequencing of cancer?; How can genome sequencing advance cancer treatment?; If I have cancer should I get my tumor genome sequenced?; Why do anticancer drugs fail and how might genomic approaches help address this issue?; Can genetics and genomics help detect early cancer and monitor treatment effectiveness?; A new approach: What is immunotherapy?; How can genomics be used to harness the patient's own immune system to fight their cancer?; 5: Solving Mystery Diseases; What is a mystery genetic disease?; How many Mendelian diseases are there?; How are genes responsible for genetic disorders identified?; How useful are genomic approaches to solving mystery genetic diseases?; Why can't most Mendelian diseases be solved?; 6: Complex genetic diseases; What is a complex genetic disease?; How do complex genetics affect neu...

Auteur

Michael Snyder, PhD, is the Stanford Ascherman Professor, Chair of the Department of Genetics, and Director of the Center of Genomics and Personalized Medicine at Stanford University. His laboratory has produced many fundamental technologies for characterizing the human genome and other "-omes," including many pivotal discoveries about our DNA. In 2012 he used his own genome sequence to predict and help diagnose his own metabolic disorder, a story that received international news attention and shined a light on the promise of genomics. Snyder a co-founder of several successful biotechnology companies, including Personalis, Protometrix (now part of Life Technologies), Affomix (now part of Illumina), and Exelixis. He is regarded as a pioneer in bringing Big Data into medicine.

Résumé
In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.

Contenu

• Acknowledgements

• Introduction

• 1: Personalized Medicine

• What is personalized medicine?

• What personal factors impact your health?

• 2: Genome Fundamentals

• What is DNA?

• What is a genome?

• What does the genome do?

• How does one person's genome differ from another person's genome?

• How do genomes of men and women differ?

• How is the genome decoded?

• 3: An Introduction to Cancer Genetics

• What is cancer and how does it arise?

• How do the BRCA1 and BRCA2 genes cause cancer?

• What are examples of other genes implicated in cancer?

• How does genetic information help us treat cancer?

• 4: Genomics and Cancer Treatment

• What has been learned from genome sequencing of cancer?

• How can genome sequencing advance cancer treatment?

• If I have cancer should I get my tumor genome sequenced?

• Why do anticancer drugs fail and how might genomic approaches help address this issue?

• Can genetics and genomics help detect early cancer and monitor treatment effectiveness?

• A new approach: What is immunotherapy?

• How can genomics be used to harness the patient's own immune system to fight their cancer?

• 5: Solving Mystery Diseases

• What is a mystery genetic disease?

• How many Mendelian diseases are there?

• How are genes responsible for genetic disorders identified?

• How useful are genomic approaches to solving mystery genetic dis…