Methods for Structural Analysis of Protein Pharmaceuticals

Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. This book explores the nature of different analytical techniques and the way in which they are related to pharmaceutical proteins. In addition to serving the analytical chemist, this book is needed by the formulation scientist who is responsible for design and formulation of a pharmaceutical protein that can be monitored during production and over time.

Explores the nature of different analytical techniques and the way in which they are related to pharmaceutical proteins

Useful for students, fellows, and research scientists who are working in the academic world and in the pharmaceutical/biotechnology industry on basic aspects of proteins.

Will help to characterize compounds so that the results can be replicated in a generic forms.

Contenu
Ultraviolet Absorption Spectroscopy.- Pluorescence Spectroscopy.- Circular Dichroism Spectroscopy.- Fourier Transform Infrared Spectroscopy.- Raman Spectroscopy.- Nuclear Magnetic Resonance Spectroscopy.- Light Scattering.- Liquid Chromatography.- Capillary Electrophoresis.- Analytical Ultracentrifugation.- Field-Flow Fractionation.- Mass Spectrometery: Protein Conformational Analysus and Molecular Recognition.- Mass Spectrometry: Proteomics.- Immunoassays.- Surface Plasmon Resonance.- Microarray-Based Methods.- Calorimetry.- Atomic Force Microscopy.- Molecular Modeling.- Concluding Remarks: Analytical Methods of Protein Formulations.