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Methods for Structural Analysis of Protein Pharmaceuticals

  • Livre Relié
  • 678 Nombre de pages
Texte du rabat Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. In the coming years, the patents on a... Lire la suite
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Description

Texte du rabat

Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. In the coming years, the patents on a number of the first-generation protein pharmaceuticals will expire, opening the door for the development of biogenerics into the market. However, it is very difficult to characterize these compounds so that the results can be replicated in a generic form. This volume details the nature of the different analytical techniques and how they are relevant for characterizing pharmaceutical proteins. In addition to serving the analytical chemist, this book is needed by the formulation scientist who is responsible for design and formulation of a pharmaceutical protein that can be monitored during production and over time. It also will be useful for students, fellows, and research scientists who are working in the academic world and in the pharmaceutical/biotechnology industry on basic aspects of proteins. TOC:Ultraviolet Absorption Spectroscopy.- Pluorescence Spectroscopy.- Circular Dichroism Spectroscopy.- Fourier Transform Infrared Spectroscopy.- Raman Spectroscopy.- Nuclear Magnetic Resonance Spectroscopy.- Light Scattering.- Liquid Chromatography.- Capillary Electrophoresis.- Analytical Ultracentrifugation.- Field-Flow Fractionation.- Mass Spectrometery: Protein Conformational Analysus and Molecular Recognition.- Mass Spectrometry: Proteomics.- Immunoassays.- Surface Plasmon Resonance.- Microarray-Based Methods.- Calorimetry.- Atomic Force Microscopy.- Molecular Modeling.- Concluding Remarks: Analytical Methods of Protein Formulations.

Contenu

Ultraviolet Absorption Spectroscopy.- Pluorescence Spectroscopy.- Circular Dichroism Spectroscopy.- Fourier Transform Infrared Spectroscopy.- Raman Spectroscopy.- Nuclear Magnetic Resonance Spectroscopy.- Light Scattering.- Liquid Chromatography.- Capillary Electrophoresis.- Analytical Ultracentrifugation.- Field-Flow Fractionation.- Mass Spectrometery: Protein Conformational Analysus and Molecular Recognition.- Mass Spectrometry: Proteomics.- Immunoassays.- Surface Plasmon Resonance.- Microarray-Based Methods.- Calorimetry.- Atomic Force Microscopy.- Molecular Modeling.- Concluding Remarks: Analytical Methods of Protein Formulations.

Détails sur le produit

Titre: Methods for Structural Analysis of Protein Pharmaceuticals
Éditeur:
Code EAN: 9780971176720
ISBN: 978-0-9711767-2-0
Format: Livre Relié
Editeur: Springer Verlag Gmbh
Genre: Médecine
nombre de pages: 678
Poids: 1402g
Taille: H254mm x B178mm x T40mm
Année: 2005
Auflage: 2005