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Methods and Biostatistics in Oncology

  • Livre Relié
  • 348 Nombre de pages
This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, purs... Lire la suite
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Description

This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach. Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology. Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal. Addressing that gap, this book discusses more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.

Auteur

Raphael L. C. Araujo is a Surgical Oncologist specialized in the diagnosis and treatment of malignant and benign injuries of the liver, pancreas and colorectal liver metastases. He spent two years (2010 / 2012) as a Research Fellow at the Hepatopancreatobiliary Service of the Memorial Sloan-Kettering Cancer Center in New York (USA). During this time, he worked on clinical research of surgical and systemic treatment of pancreatic cancer and colorectal liver metastases. Afterwards, he also spent one year as a resident of the Hepatopancreatobiliary Service at the Hospital Paul Brousse, France (2012/2013). Dr. Araujo received a PhD and concluded his postdoctoral research in Gastroenterology from the University of São Paulo School of Medicine, the same institution where he worked for 2 years as an attending physician in the Liver Surgery Unit. He is currently head of the Department of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery and Professor of the Post Graduation Program of Barretos Cancer Hospital, Barretos, São Paulo, Brazil, and Scientific Director of Brazilian Society of Surgical Oncology.

Rachel P. Riechelmann is a medical oncologist and researcher in the field of gastrointestinal cancers. She completed her formal training and PhD at the Federal University of Sao Paulo, followed by a clinical research fellowship at Princess Margaret Hospital, University of Toronto, Canada. She is currently the Director of the Department of Oncology at AC Camargo Cancer Center, which is one of the largest academic cancer centers in Brazil and Latin America, and Research Director of the Brazilian Gastrointestinal Tumors Group. Research- wise, her areas of interest and expertise are GI malignancies and Neuroendocrine Tumors as well as Methodology of Clinical Research. She has 78 publications in peer-reviewed journals and several PhD students and oncology fellows conducting projects under her supervision.



Contenu

Preface
Author: Mithat Gönen - chief of biostatistics department of Memorial Sloan-Kettering Cancer Center - NY - USA.
Background of scientific method in oncology
Author: Vinícius Vazquez - Surgical oncologist - Barretos Cancer Hospital, Barretos, São Paulo, Brazil
Writing a hypothesis for a oncology study
Author: Felipe Fregni, Harvard Medical School
Type of variables and distributions
Author: Gregory Pond, MacMaster, Hamilton, ON, Canada
Testing measures of association
Author: To be defined
Sample size calculation for oncology trials
Author: Ulrich Güller, Kantonsspital St. Gallen, 9007, St Gallen, Switzerland. ulrich.gueller@kssg.ch
Uni and multivariate analysis (understanding of regressions) in cancer research
Author: Marc Buyse, EORTC
Survival analyses in cancer trials
Author: Daniel Sargent, Mayo Clinic
The role of transversal and cohort studies in oncology
Author: To be defined
Design of retrospective and case-control studies in oncology
Author: To be defined
Minimizing differences by randomization
Author: To be defined
How to design phase I trials in oncology
Author: Lillian Siu, Princess Margert Hospital, Toronto, ON, Canada ou Carlos Gil, INCA
The many different designs of phase II oncology trials
Author: Gilberto de Castro e Paulo Hoff?
Superiority and non-inferiority phase III oncology trials
Authors: Everardo Saad, (affiliation TBD)
Phase IV oncology trials
Author:
Analysis of graphs in clinical cancer research
Author: Raphael Araujo - Upper GI and HPB Surgery department; Barretos Cancer Hospital, Barretos, SP, Brazil
Identifying biases in clinical cancer research
Author: Rachel Riechelmann, Instituto do Cancer do Estado de Sao Paulo, Universidade de São Paulo
Ethics in clinical cancer research
Author: Rodrigo Guidalini
Cost-effectiveness studies in oncology
Author: Ian Tannock, Princess Margert Hospital, Toronto, ON, Canada
How to undertake outcomes research in oncology
Author: Christopher Booth, NCI Canada, Kingston, ON
Systematic review and meta-analysis of oncology studies
Author: André Sasse
Meta-research in oncology
Author: Everardo Saad
Analysis of quality of life and patient-reported outcomes in oncology
Author: Jan
ette Vardy, University of Sidney, Australia
Exercises
Commented answers
Glossary

Détails sur le produit

Titre: Methods and Biostatistics in Oncology
Éditeur:
Code EAN: 9783319713236
ISBN: 978-3-319-71323-6
Format: Livre Relié
Genre: Médecine
nombre de pages: 348
Poids: 654g
Taille: H19mm x B241mm x T162mm
Année: 2018
Auflage: 1st ed. 2018