Medicinal Organometallic Chemistry

Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler's solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide an essential signaling molecule.

Each volume of Topics in Organometallic Chemistry provides the broad scientific readership with a comprehensive summary and critical overview of a specific topic in organometallic chemistry Research in this rapidly developing transdisciplinary field is having profound influence on other areas of scientific investigation, ranging from catalytic organic synthesis to biology, medicine and material science With contributions by international experts Includes supplementary material: sn.pub/extras

Auteur
Nils Metzler-Nolte studied chemistry in Hamburg, Freiburg and Munich, Germany. In 1994 he received his PhD for his work on synthesis, reactivity and electronic structure of alkynylboranes. After his postdoc in the laboratory of professor Green at the University of Oxford, Metzler-Nolte went to the well known Max-Planck-Institute for Bioinorganic Chemistry where he became leader of the group for bio-organometallic chemistry. Since 2000 he is professor for bioinorganic chemistry and medicinal inorganic chemistry and vice dean at the University of Heidelberg. His research is aimed at linking organometallic compounds to amino acids, small peptides and DNA analogs, namely PNAs.

Contenu
Arsenic-Based Drugs: From Fowler's Solution to Modern Anticancer Chemotherapy.- Activation Mechanisms for Organometallic Anticancer Complexes.- Organometallic Antitumour Agents with Alternative Modes of Action.- Ferrocene Functionalized Endocrine Modulators as Anticancer Agents.- Titanocenes: Cytotoxic and Anti-angiogenic Chemotherapy Against Advanced Renal-Cell Cancer.- Organometallics as Structural Scaffolds for Enzyme Inhibitor Design.- Bioorganometallic Chemistry and Malaria.- Biomedical Applications of OrganometalPeptide Conjugates.- Organometallic Radiopharmaceuticals.- Carbon Monoxide: An Essential Signalling Molecule.