SYNTHETIC AND KINETIC STUDIES OF ISOCOUMARINS AND THEIR DERIVATIVES

The work presented in this book consists of synthesis of naturally and non-naturally occurring isocoumarins and kinetic studies for the hydrolysis of isocoumarin and ketoesters. The isocoumarin, 3-n-propyl-6,7-(methylenedioxy)-1H-2-benzopyran-1- one, Xyridin A, was isolated in 1995. It has been used as folklore medicine in many countries. Its total synthesis has been carried out successfully. Another natural product, 6, 8-dihydroxy-3-[(2'-ethyl-(4''-methoxyphenyl)]-3,4- dihydro- isocoumarin, (dl)-Agrimonolide, was isolated in 1958. Partial synthesis of this isocoumarin has been carried out successfully which may be a convenient route for its total synthesis. Non-naturally occurring isocoumarins and their dihydro derivatives have been synthesized as well. They include a series of methoxyphenylisocoumarins and dihydroisocoumarins and halogenated isocoumarins and dihydroisocoumarins. In the kinetic studies, the hydrolysis of 3-(2''-chloro-6''-flurobenzyl)isocoumarin and methyl-2[2'-oxo-3'-(2"-chloro-6"-flouro- phenyl)propyl]benzoate with KOH solution were monitored to probe the mechanism of the reaction. Role of solvent in the reactions have also been investigated.

Auteur

Dr. Hafiz Badaruddin Ahmad is Physico-Organic Chemist. His main area of research is synthesis of natural products and their kinetic studies. Recently he is working on the synthesis and kinetic study of gold and silver nanoparticles.