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Pharmacokinetic / Pharmacodynamic (PK/PD) Modelling

  • Couverture cartonnée
  • 92 Nombre de pages
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Pharmacokinetic-Pharmacodynamic (PK/PD) modeling is scientific mathematical tool which integrates relationship PK model to that of... Lire la suite
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Description

Pharmacokinetic-Pharmacodynamic (PK/PD) modeling is scientific mathematical tool which integrates relationship PK model to that of PD model and a statistical model (particularly, the intra- and inter-individual variability of PK and/or PD origin). PK-PD approach is used from initial preclinical stage to last clinical phases for exploring the concentration-effect relationships executed using various approaches, such as steady state concentrations versus non-steady state concentrations models and parametric versus nonparametric models. Basing on the concentration-response invariant data basic models such as fixed-effect, linear, log-linear, Emax and sigmaoid Emax models are used. But in case of time-concentration and time-response variant conditions effect compartment, acute tolerance, sensitization and physiological indirect response models have been used. PK/PD modeling can be used as an applied science tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. Still limits of PK/PD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment.

Auteur

Mr. Dheeraj Gopu has obtained his Master's degree with Pharmacology specialization from Kakatiya University, Warangal, India. He specializes in Pharmacokinetic/Pharmacodynamic modeling of various classes of drugs. Presently he is working as a Assistant Professor in the Department of Pharmacology in Vaagdevi College of Pharmacy, K.U. Warangal, India

Informations sur le produit

Titre: Pharmacokinetic / Pharmacodynamic (PK/PD) Modelling
Auteur:
Code EAN: 9783659129186
ISBN: 978-3-659-12918-6
Format: Couverture cartonnée
Genre: Médecine
nombre de pages: 92
Poids: 139g
Taille: H5mm x B220mm x T150mm
Année: 2012
Auflage: Aufl.