Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing

The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.

Texte du rabat

The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.

Résumé
The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.

Contenu

ADAR Proteins: Structure and Catalytic Activity.- ADAR Proteins: Double-stranded RNA and Z-DNA Binding Domains.- Editing of Neurotransmitter Receptor and Ion Channel RNAs in the Nervous System.- Modulation of Micro RNA Expression and Function by ADARs.- Nuclear Editing of mRNA 3'-Untranslated Regions.- Control of ADAR1 Editing of Hepatitis Delta Virus RNAs.- Bioinformatic Approaches for Identification of A-to-I Editing Sites.- ADARs, Viruses and Innate Immunity.- Role of ADARs in Mouse Development.- Regulation and Functions of ADAR in Drosophila.- Subject index