Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Diseases: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated information on the chemistry and signaling of newly derived therapeutic nitric oxide donors/inhibitors and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. In six parts, the book discusses examples of research related to the application of novel therapeutic compounds that focus on a chemical, nitric oxide, and their applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases. This is a valuable resource for cancer researchers, oncologists, graduate students, and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. It is also highly useful for both scientists and clinicians as well as pharmaceutical companies involved in the development of new anticancer/anti-inflammatory agents.

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Part I: General introduction 1. Nitric oxide pathophysiology and applications in patients undergoing major cardiac surgery Emanuele Rezoagli Part II: Nitric oxide and cancer 2. The emerging role of dimethylarginine dimethylaminohydrolase 2 in regulating vasculogenic mimicry in cancer Arduino Mangoni 3. Recent developments of selective iNOS inhibitors as anticancer agents Part III: Nitric oxide and immunity 4. Decoding S-nitrosylation: Theoretical aspects and analytical approaches Giuseppe Filomeni 5. Preclinical Models to Assess the Pharmacological Properties of NO Derivatives Greta Varchi, Lucia Morbidelli Part IV: Nitric Oxide and aging 6. NO-mediated neuroinflammatory pathways as treatment targets in neurodegeneration Joern Steinert Part V: Nitric oxide and neurodegeneration and vascular diseases Part VI: Nitric oxide and therapeutics 7. Interactions between persulfides and nitric oxide in cardiovascular health and disease Melanie Madhani 8. Role of Nitric oxide in Gemcitabine resistance in pancreatic cancer cells Valentina Rapozzi 9. Exploring the dual role of nitric oxide in glioblastoma: Therapeutic implications Benjamin Bonavida,, Inesa Navasardyan 10. Nitric oxide donating systems and their potential in shaping tumor immunoregulation Greta Varchi