Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents

Sadik Mejid

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Presentation slides from the year 2014 in the subject Chemistry - General, grade: 1,3, University of Cologne (Anorganische Chemie...

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Presentation slides from the year 2014 in the subject Chemistry - General, grade: 1,3, University of Cologne (Anorganische Chemie), language: English, abstract: Seminar Presentation in the subject "Inorganic Chemistry" with the title "Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents". With the following contents: -The problems of the currently used anticancer drugs; - Palladium derivatives as an alternative to Platinum-based compounds; - The first Water-Soluble Iminophosphorane Ligand; - Preparation of Water-Soluble Ligand 1; - Stability of Compounds in Solution; - Cytotoxicity IC50 (µM) of Cisplatin, Ligand 1, Phosphine Oxide, TPA=O, and Metal Complexes 2-8 in Human cell lines; - The Annexin V Binding Assay; - Activity of Compounds 2 or 3 (50 µM) and Cisplatin against apoptosis-resistent cells; - Chromosomal DNA and Plasmid DNA; - Interactions of 2 and 3 with Plasmid DNA Using Electroforesis Mobility Shift Assay (EMSA); - Interaction with Human Serum Albumin; - Stern-Volmer plot for quenching with ligand 1 and compounds 2, 3, and 5 - 8 and cisplatin; - Advantage over Cisplatin; - Summery