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Progress in Theoretical Biology, Volume 5 covers the developments in theoretical biology.
The book discusses the dynamic behaviors exhibited by cellular control circuits and the role of the cell as a morphogenetic and physiological unit; the stable dynamics of genetic networks; and the organization principles and models of the function of the simplest genetic systems controlling ontogenesis. The text also describes the conceptual framework shifts in immunogenetics: the anatomy of the Ag system; the basic problems of memory in behavioural and developmental biology; and the self-organization and performance of sensory-motor codes, maps, and plans.
Physiologists, biophysicists, geneticists, mathematicians, and cytologists will find the book useful.
Contenu
Contributors
Preface
Contents of Previous Volumes
The Dynamics of Feedback Control Circuits in Biochemical Pathways
I. Introduction
II. Kinetic Equations
III. Inducible Systems
IV. Repressible Systems
V. Discussion
References
Stable Dynamics of Genetic Networks
I. Introduction
II. Connectance and Forcing Connectance
III. Connection between Forcible Functions and Internal Homogeneity
IV. Distribution of Number of Forcible Inputs among Boolean Functions
V. Density of Noncontractible Functions
VI. Metrics for Natural Boolean Order
VII. Upper Bound on Forcing Connectance
VIII. Large, Growing, Sparsely Connected Genetic Networks Condense and Have Largest Forcing Components
IX. Joint Distribution of Cycle and Disclosure Length
X. Distribution of Cycle and Disclosure Length: Predicted and Observed Effect of Forcibility
XI. Genetic and Metabolic Implications
References
Simplest Genetic Systems Controlling Ontogenesis: Organization Principles and Models of Their Function
I. Simulation of the System Controlling Phage Development
II. Some General Principles of the Organization of Bacteriophage Ontogenetic Systems
II. Kinetic Equations
III. Epigenes
References
Conceptual Framework Shifts in Immunogenetics: The Anatomy of the Ag System
I. Introduction
II. Materials and Methods
III. Complex-Simple Labeling of Sample Categories
IV. Labeling of Group II Sample Categories
V. Complex-Simple Restrictions
VI. Some Simple-Complex Pseudo-Mysteries
VII. Predictive Power of the New Framework
VIII. The Structure of Serology
IX. Summary and Conclusions
References
Communication, Memory, and Development
I. Introduction
II. Between the Devil and the Deep Blue Sea: Noise versus Saturation
III. The Statistics of Switches: Gain Control and Adaptation in On-Center Off-Surround Networks
IV. Contrast Enhancement and Short-Term Memory
V. The Statistics of Messages: Randomness Prevents Randomness
VI. Competitive Group Interactions
VII. Hysteresis, Peak Shifts, and Slow Drifts
VIII. Ratio Processing by Antagonistic Cells
IX. Slow Waves and Pacemakers
X. Long-Term Memory
XI. Reaction-Diffusion Models in Development
XII. Regeneration of Hydra's Heads
XIII. The Analogy between Regulation and Adaptation
XIV. Blastula to Gastrula in the Sea Urchin
XV. Pseudopodal Signaling and Self-Corrective Feedback
XVI. Some Experimental Tests
XVII. Production versus Directed Growth
XVIII. Biochemical Memory and the Folds of Rhodnius
XIX. Slime Mold Aggregation and Slug Motion
XX. Adhesiveness, Growth, Cell Streaming, and Division
XXI. Chemical Substrates of STM and LTM: Cyclic Nucleotides, Ions, Transmitters, and Protein Synthesis
References
A Theory of Human Memory: Self-Organization and Performance of Sensory-Motor Codes, Maps, and Plans
Introduction
Stimulus Sampling of Spatial Patterns
Sensory Codes and Motor Synergies
Ritualistic Learning of Arbitrary Acts
Nonspecific Arousal as a Command
Self-Organization of Codes and Order Information
Instrumental Conditioning
STM Reverberation until Reward Influences LTM
Rehearsal Resets STM Order Information Using Feedback Inhibition and Decouples Order and Velocity Information
An Emergent Neocortical Analog
Control of Performance Duration by STM and Arousal
Serial Learning and STM LTM Order Reversal
Storing Spatial Patterns in STM
Gain Control and Adaptation in On-Center Off-Surround Networks
Contrast Enhancement in STM
Tuning of STM and Releasing Subliminal Maps by Arousal
Adaptive Coding and the Emergence of Command Chunks
Feature Detectors
Development of an STM Code
Stabilizing the STM Code: Expectation, Resonance, Rebound, and Search
Pattern Completion, Hysteresis, and Gestalt Switching
Context-Dependent Coding and Restricted Conditions for Receding
Reset, Reaction Time, and P300
Hierarchical Critical Periods and Retrograde Amnesia
Invariance of the Past Code under Future Sequential Inputs
Bowing of the STM Pattern
Regulation of STM Primacy, Recency, and Bowing by Lateral Inhibition
Feedback Inhibition by Rehearsal in an Opaque STM Field
Transient Memory Span and Free Recall
Parallel versus Serial Search in STM
The Influence of Rehearsal on Chunking
Immediate Memory Span, and Readout of LTM Order Information by Feedback Signals from Commands
A Minimal Model of Structural versus Transient Components of Memory
Prediction
Sensory Feedback and Interference by Its Delay
Greater Weight and Longer Duration of Higher-Order Chunks
Spatio-temporal Self-Similarity and the Resolution of Uncertainty
Order-Preservation in the Future Field of Motor Commands
Masking of STM by More Cell Sites or Amplified Signals
STM Drift toward a Norm: Primary Gradient Induces Secondary Gradient
Masking of Lower-Order Codes
Clustering, Compression, Spacing, and Completion
The Magic Number Seven and Self-Similar Coding
Suppression of Uniform Patterns and Edge Detection
The Growth of On-Center Off-Surround Connections
Goal Gradient and Plans
STM Order Reversal: Item Learning versus Order Learning
Circular Reaction and Map Formation
Quenching of Irrelevant Cues
Feedforward Reset of Sequential Terminal Maps
Posture, Isometrics, Saccades, and Feedforward Motor Control
Feedforward versus Feedback Control of Sequential Map Performance
Sequential Switching between Sensory and Motor Maps
Map Reversal by Antagonistic Rebound
Imprinting, Imitation, and Sensory-Motor Algebra
Self-Tuning and Multidimensional Inference in a Parallel Processor
No Sensory Feedback Implies No Map Formation
Does the Psychophysical Power Law Influence Imitation Errors?
Rhythm and Phrasing
Reciprocal Intermodality Feedback, Internal Hearing, and Naming
Automatic versus Controlled Information Processing
Visual versus Auditory Processing and Cerebral Dominance
Concluding Remarks: Universal Adaptive Measurement
Subject Index