Mucosal Delivery of Drugs and Biologics in Nanoparticles

This book focuses on the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes.It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. Mucosal Delivery of Drugs and Biologics in Nanoparticles emphasize the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs. It acknowledges the concerns around the potential toxicity of nanoparticles to the host; few chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host's immune cells is discussed. Moreover,it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book will be the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Auteur
Dr. Muttil is an Associate Professor with tenure in the Department of Pharmaceutical Sciences, College of Pharmacy, at the University of New Mexico (UNM), NM, USA. Dr. Muttil's expertise is in developing novel delivery systems (micro-and nanotechnology) for vaccines and drugs against infectious diseases and cancers. His laboratory focuses on the formulation and testing of vaccines and drugs in animal models, as a needle-free delivery strategy. Some of the projects being pursued in his laboratory include pulmonary drug delivery for lung cancer, pulmonary immunization against tuberculosis, needle-free vaccination strategies against bioterrorism agents and formulating immunotherapeutic agents against cancers and infectious diseases. Dr. Muttil was educated in India, receiving his bachelor's in pharmacy in 1999 from the Dr. K.N. Modi Institute of Pharmaceutical and Educational Research in 1999, his master's in pharmacy from the Birla Institute of Technology & Science, Pilani, in 2001 and his PhD in pharmaceutics from the Central Drug Research Institute, Lucknow, in 2006. He did post-doctoral research in aerosol drug and vaccine delivery at the University of North Carolina, Chapel Hill, before coming to UNM in 2010. Dr. Muttil was awarded the Bill and Melinda Gates Grand Challenges Exploration grant in 2012, an award that is bestowed to only a few innovative ideas from around the world. Currently, he is also the chair of the UNM College of Pharmacy admissions committee.

Dr. Kunda is an Assistant Professor in the Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences at the St. John's University, New York, USA. Prior to joining St. John's, Dr. Kunda was a post-doctoral fellow at the College of Pharmacy, University of New Mexico, Albuquerque, NM, with a research focus in aerosol drug and vaccine delivery. Dr. Kunda received his Bachelor's in Pharmacy (Honors) from Birla Institute of Technology & Science-Pilani (BITS-Pilani), India, Master's in Drug Delivery from the London School of Pharmacy, London, UK and a Ph.D. in Formulation and Drug Delivery from Liverpool John Moores University in Liverpool, UK. Dr. Kunda's dissertation focused on developing a novel pneumococcal vaccine that can be inhaled as a dry powder.Dr. Kunda's research is multi-disciplinary and his current research interests include the use of nanotechnology in developing therapeutics against infectious disease and cancer, synthesizing polymeric nanoparticles and attaching targeting moieties for site-specific delivery, formulation of amorphous solid dispersions, immunotherapy, and drug and vaccine formulation for pulmonary delivery. Dr. Kunda's laboratory specializes in developing dry powder biologics that do not require cold-chain for storage and transport thereby decreasing the cost of biologics-based products significantly. Dr. Kunda serves as an editorial board member of PLoS One and as a Review Editor for the Vaccines and Molecular Therapeutics section of the Frontiers in Immunology and Frontiers in Public Health journals. In addition, Dr. Kunda acts a reviewer for many high-impact journals such as International Journal of Pharmaceutics, ACS Applied Materials & Interfaces, Toxicology in vitro, Pharmaceutics, Microorganisms, Pharmaceuticals, Human Vaccines & Immunotherapeutics, and PLoS One.

Résumé
Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host's immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Contenu

Section I Background.- Introduction to Nanomedicine.- Characterization of Nanoparticles.- Section II Drugs and Biologics Encapsulated in Nanoparticles.- Routes of Delivery.- Small molecule Delivery.- Peptide and Protein Delivery.- Gene Delivery (siRNA/CRISPR).- Phage Therapy.- Section III Diseases.- Non-infectious Diseases.- Infectious Diseases.- Cancer.- Section IV Host Interactions with Nanoparticles.- Interaction of Nanoparticles with Epithelial and Immune Cells.- Toxicity of Nanoparticles to the Host.- Nanoparticle Pharmacokinetics and Pharmacodynamics.- Section V MIscellanous.- Nanoparticles as Theranostics.- Regulatory Perspectives.- Manufacturing Scale-up of Nanoparticles.