Montreal, Canada, June 15-20, 1986

CHEMISTRY BIOLOGY PTERID 86.8.SYMP (COOPER ET AL) E-BOOK

Résumé
Frontmatter -- Preface -- Acknowledgments -- Contents -- How it all Began: A Brief History of the Pteridine Symposia -- The Gowland Hopkins Lecture: The Mechanisms of Action of Folate and Pterin Requiring Enzymes -- Section A: Chemistry of Pterins and Folates -- Side-Chain Chemistry of Pteridines -- A General Method for the Synthesis of 10-Substituted-10-Deaza Folate Analogues -- Synthesis and Properties of Pyrimidodiazepines as Ring-Strained Probes of Pterin Utilizing Enzymes -- Summary: Pterin and Folate Chemistry -- A Facile Method for Preparing 2,4-Diamino-5,8-Dideazapterins -- Synthesis of 5,10-Dideaza-5,6,7,8-Tetrahydrofolic Acid (DDATHF) and Analogs -- Synthetic Routes to Methotrexate- and Folic Acid-Polyglutamates of High Chemical and Enantiomeric Purity -- In Vivo and In Vitro Evaluations of 5-[4-(Substituted Aryl)-1- Piperazinyl]-6-Alkyl-2,4-Pyrimidinediamines as Antitumor Agents -- The Electrochemical Oxidation of Tetrahydropterin Derivatives -- A Practical Synthesis of (6R)- and (6S)-5,6,7,8-Tetrahydrobiopterins -- Chemical Synthesis and Properties of Quinonoid (6R)-Dihydrobiopterin -- Pyrazine-Ring Conformations of Tetrahydropterins and Quinonoid-Dihydropterins -- Hydrogenation of Silylated Pterins in Benzene Solution -- N(5)-Alkylation of Polyacetylated 5,6,7,8-Tetrahydroneopterins -- Oxidations Photosensitized by Pterins and Diaminopteridines -- Structure of the Riboflavin Synthase/Lumazine Synthase Complex. Arrangement and Chain Folding of Subunits in the Icosahedral Capsid -- Use of C18 Silica Cartridges to Purify and Characterize Pterins -- Synthesis and Structure-Activity Relationships of Tetrahydrobiopterin Cofactor Analogues -- Synthesis, Purification and Properties of a New Class of Pteridine Derivatives -- Summary: Chemistry of Pterins -- Section B: Biosynthesis and Biochemistry of Pterins -- Biosynthesis of Tetrahydrobiopterin and Related Compounds in Drosophila melanogaster -- Tetrahydrobiopterin Biosynthesis in Man -- The Biosynthesis of Tetrahydrobiopterin in the Bovine Adrenal Medulla -- The Biosynthesis of Tetrahydrobiopterin in Rat Brain -- Summary: Biosynthesis of Tetrahydrobiopterin -- The Metabolic Role of Tetrahydrobiopterin -- Spectroscopic Studies on Tyrosine 3-Monooxygenase from Bovine Adrenal Medulla: A Blue Iron Protein -- Queuine-Lacking tNRAs in Relation to the Grade of Malignancy of Specific Tumors, Possible Role of Pteridines -- Pteridine Synthesis During Interaction of Interleukin 2 with T Lymphocytes - Modulator Function in IL-2 Signal Transmission -- Section C: Biology of Pterins -- Dopamine Neurons in Culture: A Model System for Examination of Neuronal Biopterin Metabolism -- Role of the Pituitary in the Regulation of Tetrahydrobiopterin Biosynthesis in the Non-Neuronal Tissues -- Distribution of GTP Cyclohydrolase-I, Neopterin, and Biopterin in the Human Brain -- Enzymatic Synthesis of 6,7-Dimethyl-8-Ribityllumazine -- A Model for Hyperphenylal aninaemia Due to Tetrahydrobiopterin Deficiency -- The Effect of Biopterin and its Reduced Derivatives on Cultured Human Lymphocytes -- Developmental Aspects of Biopterin Metabolism in Human -- Screening for Biopterin Defects Among Hyperphenylalaninemic Patients: Report of a Canadian Program After 3 Years -- Need for Therapy in utero of Fetuses with Tetrahydrobiopterin Deficiency -- Pteridine Metabolism in Patients Suffering from Amyotrophic Lateral Sclerosis -- Urinary Neopterin in Cocaine-Abusing Individuals -- Features of Neopterin Determination in Clinical Use -- Diurnal Variation in Urinary Pterin Excretion in Man -- The Relationship between Pteridines and Colour Dimorphism in the Scorpion Fly -- Pteridine Biosynthesis and Manifestation of Pigment Phenotypes in Normal and Neoplastic Cells of Goldfish in Vitro -- Light Depending Regulations of Pteridines in the Retina -- Differences in the Regulation of Tetrahydrobiopterin Biosynthesis in Neuronal Cells in Culture -- NADPH- and NADH-Specific Dihydropteridine Reductase in Teratocarcinoma Cells in Culture: Effect of Nerve Growth Factor Treatment of the Cells on the Enzyme Activities -- Reversibility of -Diketo Reductase Activity by Sepiapterin Reductase -- Non-Enzymatic Synthesis of "Drosopterins" from Dihydropterin and 2-Amino-4-0xo-6-Acetyl-3H, 9H-7,8-Dihydropyrimido [4,5b] [1,4]Diazepine -- BH4 Biosynthesis: 1H-NMR Evidence for the Pyruvoyl-Tetrahydropterin-Synthase Catalyzed Formation of 6-Pyruvoyl-Tetrahydropterin from Dihydroneopterin Triphosphate -- Catabolism of Tetrahydrobiopterin in Man -- Pteridine Biosynthesis in Human Amniocytes and Chorionic Villi -- The Role of the Kidney in Biopterin Metabolism -- Tetrahydrobiopterin-Producing Enzyme Activities in Liver of Animals and Man -- Effect of 3-Hydroxykynurenine on GTP Cyclohydrolase Activity and on the Pteridine Pattern in Drosophila melanogaster -- Tetrahydrobiopterin Metabolism in Normal Brain, Senile Dementia of the Alzheimer Type and Down's Syndrome -- Summary: Biology of Pteridines -- Biosynthesis of...