Methods of Cancer Diagnosis, Therapy and Prognosis

This fourth volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis discusses various methodologies for the diagnosis, therapy and prognosis of Colorectal Cancer. Both standard and emerging therapies for this cancer, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume: Presents surgical, radiological, and molecular therapies and prognostic markers for colorectal cancer. Highlights a large number of methods for diagnosing colorectal cancer at various stages of development, including immunohistochemistry, in situ hybridization immunoscintigraphy, RT- PCR, free circulating DNA levels in blood and stool, ultrasonography, CT, PET, and MRI. Includes imaging technologies for assessing treatment results, and details related to colonoscopy and sigmoidoscopy. Explains the use of anticancer agents and monoclonal antibodies, including 5-fluorouracil, fluoropyrimidines, leucovorin, irinotecan, oxaliplatin, raltitrexed, capecitabine, cetuximab, and bevacizumab. * Compares preoperative chemoradiotherapy with postoperative chemoradiotherpy. The technological advances presented in this volume are expected to expedite new discoveries and their translation to clinical practice. The field of oncology will benefit the most from these advanced methods, as a combination of therapies and personalized medicine will improve early detection of colorectal cancer and other cancer types. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

Résumé

This fourth volume in a series devoted to cancer treatment discusses various methodologies for the diagnosis, therapy and prognosis of colorectal cancer. It covers the latest information including standard and emerging therapies and technological advances.

Contenu

Colorectal Cancer.- Introduction: Colorectal Cancer.- Poorly Differentiated Colorectal Adenocarcinoma (Methodology).- Colorectal Cancer: Immunohistochemical Diagnosis with Heterogeneous Nuclear Ribonucleoprotein K.- Metastases and Recurrence of Colorectal Cancer: Diagnostic Role of Immunoscintigraphy.- Colorectal Cancer Diagnosis Using DNA Levels in Blood and Stool.- Colorectal Carcinoma: Identification of MicroRNAs Using Real-Time Polymerase Chain Reaction.- Colorectal Cancer: Optimization of the Combination of 5-Fluorouracil and Irinotecan.- Detection of Abdominal Abscesses After Colorectal Surgery: Ultrasonography, Computed Tomography and Gallium Scan.- Antimetastatic Therapy in Colorectal Cancer: Role of Tumor Cell Matrix Metalloproteinase 9 (Methodology).- Endoscopic Resection of Early Colorectal Tumors: Novel Diagnostic and Therapeutic Techniques.- Role of Stromal Variables in Development and Progression of Colorectal Cancer.- Quantitative Assessment of Colorectal Cancer Perfusion: Perfusion Computed Tomography and Dynamic Contrast Enhanced Magnetic Resonance Imaging.- Positron Emission Tomography and Colorectal Cancer.- Prognostic Significance of Protein Markers in Colorectal Cancer Stratified by Mismatch Repair Status.- Colorectal Cancer: Lactate Dehydrogenase (LDH) Activity as a Prognostic Marker.- Colon Cancer.- Detection of Tumor Cells in Lymph Nodes of Colon Cancer Patients Using Real-Time Quantitative Reverse Transcription-Polymerase Chain Reaction.- Colon Cancer: Laparoscopic Surgery.- Sentinel Node-Based Immunotherapy of Colon Cancer.- Rectal Cancer.- Rectal Cancer: Preoperative Staging Using Endorectal Ultrasonography (Methodology).- Rectal Cancer: Spectral Imaging and Immunohistochemistry of Thymidylate Synthase.- Cancer of the Rectum: Abdominoperinealand Sphincter-Saving Resections.- Chemoradiation for Rectal Cancer.- Resectable Rectal Cancer: Preoperative Short-Course Radiation.- Preoperative Chemoradiotherapy Allows for Local Control in Rectal Cancer - But Distant Metastases Remain an Unsolved Problem.- Locally Advanced Rectal Cancer: Combined Chemotherapy During Preoperative Radiation Therapy.- Colorectal Liver Metastases.- Colorectal Cancer Liver Metastases: Neoadjuvant Therapy with Bevacizumab.- Colorectal Liver Metastases: Radiofrequency Ablation.- Anal Cancer.- Anal Squamous Cell Carcinomas: Diagnosis Using p63 Immunohistochemistry.- Molecular and Clinicopathologic Features Which Predict Outcome in Patients with Anorectal Melanoma.