Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.

Résumé

Metastasis (spread of cancer in the body) is the main cause of death for patients with breast cancer, the leading female tumour in the industrialised countries and developing countries alike. The biology and treatment of breast cancer metastasis remains an active area of scientific and clinical investigation.

Written by experts in the subject area, the book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies. This timely book provides the current knowledge in the area of breast cancer metastasis and will be of important reading material for oncologists, radiologists, cancer researchers, biologists and health worker.

Contenu

Metastasis of breast cancer: an introduction.- The genetic control of breast cancer metastasis.- BRCA1 in initiation, invasion, and metastasis of breast cancer: a perspective from the tumor microenvironment.- Cell motility and breast cancer metastasis.- Tight junctions and metastasis of breast cancer.- Cell adhesion molecules in breast cancer invasion and metastasis.- Endocrine resistance and breast cancer invasion.- The role of aromatase and other oestrogen producing enzymes in mammary carcinogenesis.- The role of the HGF regulatory factors in breast cancer.- The insulin-like growth factor-1 ligand in breast cancer management.- Lymphangiogenesis and metastatic spread of breast cancer.- Breast cancer secreted factors alter the bone microenvironment.- Cyclooxygenease-2 and breast cancer.- Prognostic and predictive factors in human breast cancer.- Molecular imaging in metastatic breast cancer.- Detection of disseminated tumor cells in the bone marrow and blood of breast cancer patients.- Sentinel lymph node biopsy in early-stage breast cancer.- Surgical management of patients with metastatic breast cancer.- Therapeutic aspect of metastatic breast cancer: chemotherapy.- The diagnosis and treatment of bone metastases in breast cancer.- Hormonal therapies of metastatic breast cancer: the past and the present.