Heterocyclic chemistry comprises at least half of all organic
chemistry research worldwide. In particular, the vast majority of
organic work done in the pharmaceutical and agrochemical industries
is heterocyclic chemistry.

The fifth edition of Heterocyclic Chemistry maintains the
principal objective of earlier editions - to teach the
fundamentals of heterocyclic reactivity and synthesis in a way that
is understandable to second- and third-year undergraduate chemistry
students. The inclusion of more advanced and current material also
makes the book a valuable reference text for postgraduate taught
courses, postgraduate researchers, and chemists at all levels
working with heterocyclic compounds in industry.

Fully updated and expanded to reflect important 21st
century advances, the fifth edition of this classic text includes
the following innovations:

Extensive use of colour to highlight changes in structure and
bonding during reactions
Entirely new chapters on organometallic heterocyclic chemistry,
heterocyclic natural products, especially in biochemical processes,
and heterocycles in medicine
New sections focusing on heterocyclic fluorine compounds,
isotopically labeled heterocycles, and solid-phase chemistry,
microwave heating and flow reactors in the heterocyclic
context

Essential teaching material in the early chapters is followed by
short chapters throughout the text which capture the essence of
heterocyclic reactivity in concise resumés suitable as
introductions or summaries, for example for examination
preparation. Detailed, systematic discussions cover the reactivity
and synthesis of all the important heterocyclic systems. Original
references and references to reviews are given throughout the text,
vital for postgraduate teaching and for research scientists.
Problems, divided into straightforward revision exercises, and more
challenging questions (with solutions available online), help the
reader to understand and apply the principles of heterocyclic
reactivity and synthesis.

Auteur
John Joule is Emeritus Professor in the School of Chemistry, The University of Manchester, UK Keith Mills spent 25 years in the Medicinal Chemistry and Development Chemistry departments at GlaxoSmithKline, Stevenage, UK, and is now an independent consultant.

Texte du rabat
Heterocyclic chemistry is a central part of organic chemistry and biochemistry. The term refers to a particular set of chemical structure characteristics, with many drugs and specialty chemicals, and most agrochemicals, containing these characteristics. Heterocyclic Chemistry by Joule & Mills has established itself as the premier textbook of heterocyclic chemistry, used by high level undergraduates, postgraduates and industrial researchers all over the world.

Heterocyclic Chemistry covers the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. It also includes more advanced material, making the book appropriate for postgraduate taught courses and to researchers, either at postgraduate degree level or those working with heterocyclic compounds in industry. Essential teaching material is collected in specific introductory chapters, explaining the principles of heterocyclic reactivity in the simplest terms, suitable either as introductions or as summaries for examination preparation. These chapters are augmented by detailed, systematic discussions of the chemical reactivity of particular heterocyclic systems. References to both primary literature and reviews are given throughout the text, and whilst these are essential for postgraduate teaching and to research workers, they do not interfere with the readability of the text for undergraduate students.

Résumé
This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry.

The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry.

Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations:

Extensive use of colour to highlight changes in structure and bonding during reactions
Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine
New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context
Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

Contenu

Preface to the Fifth Edition xix

P.1 Hazards xxi

P.2 How to Use This Textbook xxi

Acknowledgements xxii

References xxii

Web Site xxii

Biography xxiii

Definitions of Abbreviations xxv

1 Heterocyclic Nomenclature 1

2 Structures and Spectroscopic Properties of Aromatic Heterocycles 5

3 Substitutions of Aromatic Heterocycles 19