CHF118.90
Download est disponible immédiatement
Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. * Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, *Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.
Contenu
I. Genome Instability of Viruses
II. Genome instability in Bacteria and Archaea
Genome instability in bacteria and archaea: Strategies for maintaining genome stability Jan-Erik Messling and Ashley B. Williams
Genome instability in bacteria: causes and consequences Ashley B. Williams
CRISPR - bacteria immune system Andrey Golubov
III. Genome Stability of Unicellular Eukaryotes
Programmed DNA rearrangement in ciliates Franziska Jönsson
Homologous Recombination and Non-homologous End-joining repair in yeast Rebecca E. Jones and Timothy C. Humphrey
IV. Genome stability in multicellular eukaryotes
Meiotic and Mitotic Recombination: First in Flies Julie Korda Holsclaw, Talia Hatkevich and Jeff Sekelsky
Genome stability in Drosophila - mismatch repair and genome stability Tomoe Negishi
Genome stability in Caenorhabditis elegans Matthias Rieckher, Amanda Franqueira C. Lopes and Björn Schumacher
Genetic Engineering of Plants using Zn-fingers, TALENs and CRISPRs Andriy Bilichak and Francois Eudes
Plant Genome Stability - General Mechanisms Andriy Bilichak
V. Genome stability in mammals
Cell cycle control and DNA damage signalling in mammals Valenti Gomez and Alexander Hergovich
The role of p53/p21/p16 in DNA damage signalling and DNA repair Yavuz Kulaberoglu, Ramazan Gundogdu, and Alexander Hergovich
Roles of RAD18 in DNA Replication and Post-Replication Repair (PRR) Cyrus Vaziri, Satoshi Tateishi, Liz Mutter-Rottmayer and Yanzhe Gao
Base Excision Repair and Nucleotide Excision Repair Tadahide Izumi and Isabel Mellon
DNA Mismatch Repair in Mammals Mingzhang Yang and Peggy Hsieh
Repair of double strand breaks by non-homologous end joining; its components and their function Patryk Moskwa
Double-Strand Break Repair: Homologous Recombination in Mammalian Cells Camille Gelot, Tangui Le-Guen, Sandrine Ragu and Bernard S. Lopez
Telomere maintenance and genome stability Wilnelly Hernandez-Sanchez, Mengyuan Xu and Derek J. Taylor
The relationship between checkpoint adaptation and mitotic catastrophe in genomic changes in cancer cells Lucy H. Swift and Roy M. Golsteyn
Chromatin, nuclear organization and genome stability in mammals Lora Boteva, Nick Gilbert
Role of DNA methylation in genome stability Dan Zhou and Keith D. Robertson
Non-coding RNAs in genome integrity Igor Kovalchuk
VI. Human diseases associated with genome instability 26. Human diseases associated with genome instability Bruno César Feltes, Joice de Faria Poloni, Kendi Nishino Miyamoto and Diego Bonatto
Cancer and genomic instability Wei Wei, Yabin Cheng and Bo Wang
Chromatin Modifications in DNA Repair and Cancer Margaret Renaud-Young, Karl Riabowol and Jennifer Cobb
Genomic Instability and Aging - Causes and Consequences Corinne Sidler
Nucleolar contributions to DNA damage response and genomic (in)stability in the nervous system Michal Hetman
VII. Effect of environment on genome stability
Diet and nutrition Lynnette R. Ferguson
Chemical mutagenesis
Environmental sources of ionizing radiation and their health consequences Aaron A. Goodarzi, Alexander Anikin, Dustin D. Pearson
Section VIII. Bystander and transgenerational effects - epigenetic perspective
Epigenetics of transgenerational genome instability in mammals
Genomic Instability and the Spectrum of Response to Low Radiation Doses Carmel Mothersill and Colin Seymour
Transgenerational genome instability in plants Igor Kovalchuk
Methods for the detection of DNA damage Denis V. Firsanov, Ljudmila V. Solovjeva, Vyacheslav M. Mikhailov, Maria P. Svetlova
Conserved and divergent features of DNA repair. Future perspectives in genome instability research Igor Kovalchuk