Genetics of Autoimmunity

This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.

Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title:

• descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific

• discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.

Auteur
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Contenu

Symposiumon Genomics of autoimmunity, held at the Novartis
Foundation, London, 22-24 June, 2004.

Editors: Gregory Bock (Organizer) and Jamie Goode.

This symposium is based on a proposal by Abul Abbas, David
Hafler and John Rioux.

Abbul Abbas: Chair's introduction.

Mark Daly: Patterns of genetic variation in humans and
mice.

Discussion.

David B. Goldstein: Haplotype tagging in
pharmacogenetics.

Discussion.

Simon J. Foote, Justin P. Rubio, Melanie Bahlo, Trevor J.
Kilpatrick, Terence P. Speed, Jim Stankovich, Rachel Burfoot,
Helmut Butzkueven, Laura Johnson, Chris Wilkinson, Bruce Taylor,
Michele Sale, Ingrid A. F. van derMei, Joanne L. Dickinson and
Patricia Groom: Multiple sclerosis: a haplotype association
study.

Discussion.

Juha Kere: Mapping genes for asthma and psoriasis.

Discussion.

Linda S. Wicker, Carolyn L. Moule, Heather Fraser, Carlos
Penha-Goncalves, Dan Rainbow, Valerie E. S. Garner, Giselle
Chamberlain, Kara Hunter, Sarah Howlett, Jan Clark, Andrea
Gonzalez-Munoz, Anne Marie Cumiskey, Paul Ti¡en, Joanna
Howson, Barry Healy, Luc J. Smink, Amanda Kingsnorth, Paul A.
Lyons, Simon Gregory, Jane Rogers, John A.Todd and Laurence B.
Peterson: Natural genetic variants influencing type 1 diabetes
in humans and in the NOD mouse.

Discussion.

Srividya Subramanian and Edward K. Wakeland: The importance
of epistatic interactions in the development of
autoimmunity.

Discussion.

Timothy J. Vyse, Angela Richardson, EmilyWalsh, Lisa Farwell,
MarkJ. Daly, Cox Terhorst and John D. Rioux: Mapping autoimmune
disease genes in humans: lessons from IBD and SLE.

Discussion.

Cisca Wijmenga and Martin C. Wapenaar: A combined genetics
and genomics approach to unravelling molecular pathways in coeliac
disease.

Discussion.

Timothy W. Behrens, Robert R. Graham, Chieko Kyogoku, Emily C.
Baechler, Paula S. Ramos, Clarence Gillett, Jason Bauer, Ward A.
Ortmann, Keli L. Hippen, Erik Peterson, Carl D. Langefeld, Kathy
L.Moser, Patrick M. Ga¡neyand Peter K. Gregersen: Progress
towards understanding the genetic pathogenesis of systemic lupus
erythematosus.

Discussion.

Vigo Heissmeyer, Fernando Maciä n, Rajat Varma, Sin-Hyeog
Im, Francisco García-Cozar, Heidi F.Horton, Michael C. Byrne,
Stefan Feske, K. Venuprasad, Hua Gu, Yun-Cai Liu, Michael L. Dustin
and Anjana Rao: A molecular dissection of lymphocyte
unresponsiveness induced by sustained calcium signaling.

Discussion.

Adrian Liston and Christopher C. Goodnow: Genetic lesions in
thymicTcell clonal deletion and thresholds for
autoimmunity.

Discussion.

Lalitha Vijayakrishnan, Jacqueline M. Slavik, Zsolt Illés,
Dan Rainbow, Laurence B. Peterson, Arlene S. Sharpe, Linda S.
Wickerand, Vijay K. Kuchroo: An autoimmune disease-associated
CTLA4 splice variant lacking the B7 binding domain signals
negatively in Tcells.

Discussion.

Adrian Ting, Stefan Lichtenthaler, Ramnik Xavier, Soon-Young Na,
Shahrooz Rabizadeh,TaraHolmes and Brian Seed: Large-scale
screens for cDNAs with in vivo activity.

Discussion.

Jenny Ting: Genomic mining of new genes and pathways in
innate and adaptive Immunity.

Discussion.

Index of contributors.

Subject index.