CHF275.00
Download est disponible immédiatement
Das erste Referenzwerk dieser Art mit einer umfassenden und dennoch prägnanten Einführung in die Epigenetik beschäftigt sich mit den unzähligen Interaktionen zwischen Hormonregulation und Epigenetik. Die Inhalte sind gut strukturiert. Es gibt keine Überschneidungen zwischen den Kapiteln und jedes Kapitel beinhaltet Zusatzmaterialien für Präsentationen. Der Schwerpunkt liegt durchgängig auf Erkrankungen. Zielgruppe sind die vielen Physiologen und Entwicklungsbiologen, die zwar mit der Bedeutung und den Mechanismen der Hormonregulation vertraut sind, aber über unzureichendes Hintergrundwissen im Bereich Epigenetik verfügen.
Auteur
Subhrangsu S. Mandal is currently Associate Professor at the Department of Chemistry and Biochemistry, at The University of Texas at Arlington, Texas. He received his PhD degree from the Indian Institute of Science, Bangalore, where he worked on chemical nucleases and cationic liposome-mediated gene delivery in the laboratory of Professor S. Bhattacharya. He joined the laboratory of Professor Linda J. Reha-Krantz as an Alberta Heritage Foundation for Medical Research (AHFMR) postdoctoral fellow in the University of Alberta, Canada. He later moved to the laboratory of Professor Danny Reinberg to research on eukaryotic transcription and gene regulation in human at the University of Medicine and Dentistry of New Jersey (UMDNJ)/Howard Hughes Medical Institute (HHMI). Prof. Mandal began his independent career at University of Texas at Arlington in 2005. Specifically he is investigating the function of Mixed Lineage Leukemia (MLL) family of histone methyl-transferases in gene activation, estrogen signalling, and tumorigenesis. In parallel, the Mandal laboratory is also developing novel gene targeted cancer therapy using mouse models.
Résumé
The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Contenu
Preface XIII
Volume I
**1 Eukaryotic Gene Expression by RNA Polymerase II 1
**Geetha Durairaj, Shivani Malik, and Sukesh R. Bhaumik
1.1 Introduction 1
1.2 Transcriptional Initiation of RNA Polymerase II Genes 1
1.3 Transcriptional Elongation of RNA Polymerase II Genes 5
1.4 Transcriptional Termination of RNA Polymerase II Gene 8
1.5 Capping of mRNA at the 5´-End 9
1.6 Processing of mRNA at the 3´-End 10
1.7 Splicing of mRNA 11
1.8 Nuclear Export of mRNA for Translation 13
1.9 Conclusion 17
References 17
**2 Epigenetic Code: Histone Modification, Gene Regulation, and Chromatin Dynamics 29
**Arunoday Bhan, Paromita Deb, and Subhrangsu S. Mandal
2.1 Introduction 29
2.2 Histone Modifications 31
2.2.1 Histone Acetylation and Deacetylation 31
2.2.2 Histone Lysine Methylation 33
2.3 Histone Lysine Demethylation 38
2.4 Histone Arginine Methylation 39
2.5 Histone Phosphorylation and Dephosphorylation 40
2.6 Histone ADP-Ribosylation 42
2.7 Histone Ubiquitination 43
2.8 Epigenetic Code Hypothesis and Conclusion 44
Acknowledgments 48
List of Abbreviations 48
References 49
**3 Histone Lysine Methylation, Demethylation, and Hormonal Gene Regulation 59
**Yaling Huang, Briana Dennehey, and Xiaobing Shi
3.1 Introduction 59
3.2 The Enzymes That Catalyze Histone Lysine Methylation and Demethylation 60
3.2.1 Lysine Methyltransferases (KMTs) 61
3.2.2 Lysine Demethylases (KDMs) 75
3.3 Histone Lysine Methylation in Hormone Signaling 78
3.3.1 Hormone Receptor Classification 78
3.3.2 Estrogen Receptor-Like Subfamily 80
3.3.3 Thyroid Hormone Receptor-Like Subfamily 85
3.3.4 Retinoid X Receptor-Like Subfamily 86
3.3.5 Nerve Growth Factor 1B-Like Subfamily 87
3.3.6 Steroidogenic Factor-Like Subfamily 87
3.4 Perspectives 87
Acknowledgments 88
Abbreviations 88
References 89
**4 The Role of HATs and HDACs in Cell Physiology and Disease 101
**Irene Santos-Barriopedro, Helena Raurell-Vila, and Alejandro Vaquero
4.1 Introduction 101
4.2 HATs and HDACs 102
4.2.1 HATs 102
4.2.2 HDACs 104
4.3 Acetylation/Deacetylation in Chromatin-Associated Functions 107
4.3.1 HATs, HDACs, and Transcription 107
4.3.2 Chromatin Structure and Heterochromatin 110
4.3.3 HATs and HDACs in DNA Repair 111
4.4 HATs and HDACs in Cell Physiology 113
4.4.1 Cell-Cycle Regulation 113
4.4.2 Apoptosis, Aging, and Senescence 115
4.4.3 Differentiation and Development 117
4.4.4 Metabolism 120
4.5 Associated Diseases 122
4.5.1 Cancer 123
4.5.2 Vascular Diseases 126
4.5.3 Neurodegenerative Diseases 127
4.5.4 Other Diseases 127
References 127
**5 The Short and Medium Stories of Noncoding RNAs: microRNA and siRNA 137
**Arunoday Bhan, Paromita Deb, Milad Soleimani, and Subhrangsu S. Mandal
5.1 Introduction 137
5.2 MicroRNA 140
5.2.1 Discovery of miRNAs 140
5.2.2 Biogenesis of miRNA 141
5.2.3 Processing of miRNA and its Mechanism of Action 141
5.2.4 Functional Significance of miRNA 144
5.2.5 Association of miRNAs with Human Diseases and Cancer 148
5.3 Small Interfering RNA (siRNA) 151
5.3.1 Discovery of siRNAs 151
5.3.2 Biogenesis of siRNAs 152
5.3.3 Processing and Mechanism of Action of siRNAs 153
5.4 Piwi interacting RNA 154
5.5 Transcription Initiating RNAs (TiRNAs) 155
5.6 Small Nuclear RNAs (snRNAs) 155
5.7 Conclusion 156
Acknowledgments 157 &...