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DNA Methylation, Epigenetics and Metastasis

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This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of meta... Lire la suite
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Description

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis. TOC:How CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes.- A Mouse Skin Multistage Carcinogenesis Model that Unmasks Epigenetic Lesions Responsible for Metastasis.- CpG Island Hypermethylation and Lung Cancer Invasion and Metastasis.- CpG Island Hypermethylation Changes During Prostate Cancer Progression and Metastasis.- CpG Island Hypermethylation in Breast Cancer Progression and Metastasis.- Epigenettic Dysregulation of Maspin (SerpinB5) in Cancer Invasion and Metastasis.- Epigenetic Regulation of the E-cadherin Cell-Cell Adhesion Gene.- Epigenetic Disruption of the SLIT-ROBO Interactions in Human Cancer.- Molecular Mechanisms of the Metastasis-Associated Gene Family of Coregulators: Role in Cancer and Invasion.- The Molecular Mechanisms for BRMS1 Action in Cancer Metastasis.- Mechanisms of DNA Demethylating Drugs Against Cancer Progression.- Histone Deacetylase Inhibitors: Novel Targeted Anti-Cancer Agents.

Contenu
Chapter 1: How CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes. Manel Esteller Chapter 2: A Mouse Skin Multistage Carcinogenesis Model that Unmasks Epigenetic Lesions Responsible for Metastasis. Mario F. Fraga & Manel Esteller Chapter 3: CpG Island Hypermethylation and Lung Cancer Invasion and Metastasis. Ubaradka G. Sathyanarayana & Adi F. Gazdar Chapter 4: CpG Island Hypermethylation Changes During Prostate Cancer Progression and Metastasis. Srinivasan Yegnasubramanian & William G. Nelson Chapter 5: CpG Island Hypermethylation in Breast Cancer Progression and Metastasis. Paola Parrella Chapter 6: Epigenettic Dysregulation of Maspin (SerpinB5) in Cancer Invasion and Metastasis. Bernard W. Futscher & Frederick E. Domann Chapter 7: Epigenetic Regulation of the E-cadherin Cell-Cell Adhesion Gene. Hector Peinado & Amparo Cano Chapter 8: Epigenetic Disruption of the SLIT-ROBO Interactions in Human Cancer. Ashraf Dallol, Rachel E. Dickinson & Farida Latif Chapter 9: Molecular Mechanisms of the Metastasis-Associated Gene Family of Coregulators: Role in Cancer and Invasion. Seetharaman Balasenthil & Rakesh Kumar Chapter 10: The Molecular Mechanisms for BRMS1 Action in Cancer Metastasis. Rajeev S. Samant & Lalita A. Shevde Chapter 11: Mechanisms of DNA Demethylating Drugs Against Cancer Progression. Zunyan Dai, Kavitha Kosuri & Gregory A. Otterson Chapter 12: Histone Deacetylase Inhibitors: Novel Targeted Anti-Cancer Agents. Paul Marks & William Kevin Kelly.

Informations sur le produit

Titre: DNA Methylation, Epigenetics and Metastasis
Éditeur:
Code EAN: 9781402036422
ISBN: 978-1-4020-3642-2
Protection contre la copie numérique: filigrane numérique
Format: eBook (pdf)
Producteur: Springer-Verlag GmbH
Editeur: Springer
Genre: Médecine
nombre de pages: 310
Parution: 30.03.2006
Année: 2006
Taille de fichier: 3.0 MB