This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism as discussed at the 33rd Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) will be held in Brisbane, Queensland, Australia, August 2005. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology. TOC:Anticoagulant Blood Factor Deficiencies (Protein C).- Hemorheological Aspects In The Microvasculature Of Pathologies.- Clonidine Elicits A Long-Term Depression In Mucosal Red Cell Flux.- Real-Time, Automated, Fluorophore Mediated Multi-Cardiac Marker Biosensing System With Nano-Metallic Particle Reagent.- Pten And Ndufb8 Aberrations In Cervical Cancer Tissue.- Prediction Of Surgical Site Infections After Major Surgery Using Visible And Near-Infrared Spectroscopy.- Application Of Novel Metal Nanoparticles As Optical/Thermal Agents In Optical Mammography And Hyperthermic Treatment For Breast Cancer.- Possible Mechanisms Of Improved Radiation Response By Cytotoxic Rnase, Onconase, On A549 Human Lung Cancer Xenografts Of Nude Mice.- Effect Of Ph And Imidazole On Protein C Purification From Cohn Fraction Iv-1 By Imac.- Predicting Melanoma Metastatic Potential By Optical And Magnetic Resonance Imaging.- Analysis Of Sdhd And Mmp12 In An Affected Solar Keratosis And Control Cohort.- Wyman's Equation And Oxygen Flux Through The Red Cell.- Simultaneous Measurement Of Po2 And Perfusion In The Rabbit Kidney In Vivo.- Pseudogenes And The Electron Transport Chain.- Intratumoral Vegf And Fgf1 Administration Alters Tumor Expression Of Mcp-1 And Interleukins.- Nitric Oxide In The Kidney; Direct Measurements Of Bioavailable Renal Nitric Oxide.- Separation Of Protein C From Cohn Fraction Iv-1 By Mini-Antibody.- The Role Of Atp Sensitive Channels In Insulin Secretion And The Implications In Persistent Hyperinsulinemic Hypoglycaemia Of Infancy (Phhi).- Triptolide Alters Mitochondrial Functions.-Immunohistochemical Identification And Localization Of Endogenous Endostatin And Its Related Peptides In Murine Tumors.- Impact Of Hypoxic And Acidic Extracellular Conditions On Cytotoxicity Of Chemotherapeutic Drugs.- Brief Exposure To -2 Gz Reduces Cerebral Oxygenation In Response To Stand Test.- Normal Cardiac Output, Oxygen Delivery And Oxygen Extraction.- Near Infra-Red Spectroscopy And Arterial Oxygen Extraction At Altitude.- Oxygen Delivery At Sea Level And Altitude (After Slow Ascent To 5000 Meters), At Rest And In Mild Exercise.- Increased Sensitivity To Transient Global Ischemia In Aging Rat Brain.- Single Breath Tracing For Carbon Dioxide In Septic Patients With Tissue Hypoxia.

Résumé
At the beginning of a Southern Hemisphere Autumn, the ISOTT tribe assembled for its annual corroboree on the banks of the Brisbane River in Australia for five days of exciting science. Some of the tribe had travelled from as far as Sweden and other parts of Europe; many had spirited themselves across the Pacific Ocean from the Americas. Yet another small contingent had paddled down from Japan. All came with message sticks from their camp-sites. The conference opened with an outdoor barbecue at the Southbank precinct, with the stars of the Southern Cross painting the river on one side and the artificial beach on the other; a perfect venue to meet old friends and to welcome new ones as a cool breeze wafted over our fires. For the next five days there was the usual focus on oxygen; measurement techniques, its role in cancer and other diseases that beset us mortals and the biochemistry and physiology of this small vital molecule. It still astounds many that we have not yet learnt everything there is to know about this valuable friend, albeit a dangerous foe. Time was found for us to visit Australia Zoo and stand in awe before exhibits of Australia's wild-life; great vicious creatures unchanged from the age of the dinosaurs, poisonous snakes and spiders, and gentle marsupials that posed for our digital cameras.

Contenu
Anticoagulant Blood Factor Deficiencies (Protein C).- Hemorheological Aspects in The Microvasculature of Several Pathologies.- Clonidine Elicits A Long-Term Depression in Mucosal Red Cell Flux.- Real-Time, Automated, Fluorophore Mediated Multi-Cardiac Marker Biosensing System with Nano-Metallic Particle Reagent.- Pten and Ndufb8 Aberrations in Cervical Cancer Tissue.- Prediction Of Surgical Site Infections After Major Surgery Using Visible And Near-Infrared Spectroscopy.- Application Of Novel Metal Nanoparticles As Optical/Thermal Agents In Optical Mammography And Hyperthermic Treatment For Breast Cancer.- Possible Mechanisms Of Improved Radiation Response By Cytotoxic Rnase, Onconase®, On A549 Human Lung Cancer Xenografts Of Nude Mice.- Effect Of Ph And Imidazole On Protein C Purification From Cohn Fraction Iv-1 By Imac.- Predicting Melanoma Metastatic Potential By Optical And Magnetic Resonance Imaging.- Analysis of Sdhd and Mmp12 in an Affected Solar Keratosis and Control Cohort.- Wyman's Equation and Oxygen Flux Through The Red Cell.- Simultaneous Measurement of pO2 and Perfusion in The Rabbit Kidney in Vivo.- Pseudogenes and The Electron Transport Chain.- Intratumoral Vegf and Fgf1 Administration Alters Tumor Growth, Vascular Density, Oxygenation, and Expression of Mcp-1 and Interleukins.- Nitric Oxide in The Kidney Direct measurements of bioavailable renal nitric oxide.- Separation Of Protein C From Cohn Fraction Iv-1 By Mini-Antibody.- The Role of ATP Sensitive Channels in Insulin Secretion and The Implications in Persistent Hyperinsulinemic Hypoglycaemia of Infancy (PHHI).- Triptolide Alters Mitochondrial Functions.- Immunohistochemical Identification And Localization Of Endogenous Endostatin And Its Related Peptides In Murine Tumors.- Impact Of Hypoxic AndAcidic Extracellular Conditions On Cytotoxicity Of Chemotherapeutic Drugs.- Brief Exposure To 2 G Z Reduces Cerebral Oxygenation In Response To Stand Test.- Normal Cardiac Output, Oxygen Delivery And Oxygen Extraction.- Near Infra-Red Spectroscopy And Arterial Oxygen Extraction At Altitude.- Oxygen Delivery at Sea Level and Altitude (After Slow Ascent to 5000 Meters), at Rest and in Mild Exercise.- Increased Sensitivity to Transient Global Ischemia in Aging Rat Brain.- Single Breath Tracing for Carbon Dioxide in Septic Patients with Tissue Hypoxia.