Preparation of PotassiumDicitro Bismuthate Complex as Antigastric Ulcer

Scientific Essay from the year 2011 in the subject Chemistry - Anorganic Chemistry, grade: 3, University of Mosul (DBS), language: English, abstract: The present study was designed to synthesis potassium dicitro bismuthate (III) complex. The complex was characterized by infrared spectra, conductivity and elemental analysis of Bi. The effect of gastro protection was investigated for the prepared complex against HCl- ethanol induced ulcer in rats. The complex was administered to rats at 50 and 100 mg\kg doses orally before one hour of receiving 0.2ml of HCl- ethanol mixture to induce gastric ulcer. Sucralfate (100mg\ kg, orally) was used as standard drug. The severity of gastro mucosal damage induced by HCl-ethanol was analyzed in term of ulcer index value. Administration of potassium dicitro bismuthate (III) one hour before HCl-ethanol had significantly decreased ulcer index value when compared to saline treated group. Sucralfate (100mg\kg, orally) also produced a significant decrease in ulcer index when compared with the saline treated group. There was no significant difference between potassium dicitro bismuthate (III) and Sucralfate in degree of protection against ulcer. Thus it can be concluded that potassium dicitro bismuthate (III) has antiulcer activity in rats.

Auteur

Amer A. Taqa: Professor at Dental Basic Science, College dentistry, Mosul University, Iraq. Have PhD degree in Dental chemistry. He has published more 100 researches papers in national and international academic journals and authored 22 books. His research interests include dental chemistry, medical chemistry, and inorganic chemistry. He is editorial member in more than 140 international journals. He Nominated as a member of the organizing committees for a number of international and local conferences. E-mail: amertaqa@hotmail.com Publons: https://publons.com/a/331136 ORCID: http://orcid.org/0000-0002-3104-0078