Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.

Auteur

AKHLAQ FAROOQUI is an Adjunct Associate Professor of Medical
Biochemistry at Ohio State University. He is author of over 180
peer-reviewed research articles, and author/editor of eight books
and an expert in fields of glycerophospholipid metabolism,
excitotoxicity, bioactive ether lipids, and phospholipases A2 in
brain.

TAHIRA FAROOQUI is a Research Scientist in the Department
of Entomology at Ohio State University. She is the author of 40
peer-reviewed research articles and several monographs and an
expert on glycerophospholipid and sphingolipid metabolism, biogenic
amines, and neural plasticity.

Texte du rabat

Metabolic syndrome is a recognized suite of biological risk factors that increase the likelihood of developing long-term health problems including a wide range of neurological disorders. Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - obesity, insulin resistance, and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.

Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to connect metabolic syndrome with neurological disorders ranging from stroke to neurodegenerative diseases. Chapters also look at how other factors such as oxidative stress and inflammation may play a role in disease development.

Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, Metabolic Syndrome and Neurological Disorders is a valuable reference for researchers and clinicians in the field.

• Comprehensive coverage of the molecular mechanisms behind the link between metabolic syndrome and stroke, Alzheimer disease, and depression
• Timely investigation of a health issue which will be of increasing importance given the aging of the world's population
• Written by leaders in the field of metabolic syndrome
• Unique, accessible exploration of a topic with relevance for a wide variety of disciplines, including neuroscientists, pharmacologists, and clinicians

Résumé

Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.

Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.

Contenu

Foreword Mark P. Mattson xi

Preface Tahira Farooqui and Akhlaq A. Farooqui xiii

Acknowledgments Tahira Farooqui and Akhlaq A. Farooqui xv

Contributors xvii

1 Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease 1
Suzanne M. de la Monte and Ming Tong

2 Insulin Receptor and the Pathophysiology of Alzheimer Disease 31
Johanna Zemva and Markus Schubert

3 Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease 51
Adnan Erol

4 InsulinLeptin Signaling in the Brain 75
Vicente Barrios, Emma Burgos-Ramos, and Jes´us Argente

5 The Janus Face of Insulin in Brain 85
Ana Duarte, Emanuel Candeias, S´onia C. Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I. Pl´acido, Maria S. Santos, Catarina R. Oliveira, and Paula I. Moreira

6 Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease 115
Maite Solas and Maria J. Ram´ýrez

7 Contribution of Phospholipid, Sphingolipids, and Cholesterol-Derived Lipid Mediators in the Pathogenesis of Metabolic Syndrome and Neurological Disorders 137
Akhlaq A. Farooqui and Tahira Farooqui

8 Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated
Neurotoxicity 163
Mun'delanji C. Vestergaard, Masamune Morita, Tsutomu Hamada, and Masahiro Takagi

9 Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals 179
Giulio Maria Pasinetti, Amanda Bilski, Lap Ho, Jun Wang, Mario Ferruzzi, Masahito Yamada, Kenjiro Ono, and Salvatore Mannino

10 Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction 191
Jae-Sung Lim and Hyung-Min Kwon

11 Neurochemical Linkage Among Metabolic Syndrome, Alzheimer Disease, and Depression 197
Undurti N. Das

12 Alterations in the Endocannabinoid System as a Link Between Unbalanced Energy Homeostasis, Neuroinflammation, and Neurological and Neuropsychiatric Disorders 219
Tiziana Bisogno and Vincenzo Di Marzo

13 Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides 235
George Anderson and Michael Maes

14 Binge Eating and Metabolic Syndrome 249
Ignacio J´auregui-Lobera

15 Phytochemical Principles in the Traditional Indian System of Medicine Used for the Management of Metabolic Syndrome 261
Syed Ibrahim Rizvi and Neetu Mishra

16 Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome 275
Morihiro Matsuda and Iichiro Shimomura

17 The Relationship Among Obesity, Inflammation, and Insulin Resistance 283
Jean-Philippe Bastard and Bruno F`eve

18 Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome 297
Hardik Gandhi and Ramachandran Balaraman

19 Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue 311
Paolo Calabro, Enrica Golia, Valeria Maddaloni, Giuseppe Limongelli, Brunella Ziello, Fabio Fimiani, Ilaria Jane Romano, Mario Crisci, Maria Giovanna Russo, Edward T.H. Yeh, and Raffaele Calabro

20 Is Diabetes a Risk Factor for Parkinson Disease? 327
Akhlaq A. Farooqui and Tahira Farooqui

21 Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome 335
Lu Cai **22 Contributions of AMP Kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerativ...