The Chemokine System in Experimental and Clinical Hematology

This comprehensive explanation of the importance of the chemokine system in hematology focuses on the development of hematologic malignancies, including the immunobiology of stem cell transplantation. It shows that chemokines can be involved in leukemogenesis.

The aim of the issue is to describe and explain the importance of the chemokine system in hematology. The chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation. The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as for immunoregulation in patients treated with allogeneic stem cell transplantation. Thus, chemokines are important both for the pathogenesis and treatment of hematological diseases.

Contenu
The Chemokine System in Experimental and Clinical Hematology.- Chemokine Decoy Receptors: StructureFunction and Biological Properties.- Role of Chemokines in the Biology of Natural Killer Cells.- Chemokines in Angiogenesis.- Genetic Polymorphisms in the Cytokine and Chemokine System: Their Possible Importance in Allogeneic Stem Cell Transplantation.- The Chemokine System: A Possible Therapeutic Target in Acute Graft Versus Host Disease.- Homing in on Acute Graft vs. Host Disease: Tissue-Specific T Regulatory and Th17 Cells.- The Chemokine Network in Acute Myelogenous Leukemia: Molecular Mechanisms Involved in Leukemogenesis and Therapeutic Implications.- CXCR4 in Clinical Hematology.- Immunobiology of Heparin-Induced Thrombocytopenia.