Sinusoidal Cells in Liver Diseases: Role in Their Pathophysiology, Diagnosis, and Treatment

Texte du rabat

Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics.

Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure.

Contenu

Section 1 The liver sinusoid General concepts 1. The unique architecture of the hepatic sinusoid 2. Sinusoidal cells interactions from soluble factors to exosomes 3. Sinusoidal cells and liver immunology 4. Microscopic imaging of the hepatic sinusoid 5. The liver sinusoid at single cell level 6. Advanced models to study the liver sinusoid 7. Aging and the liver sinusoid

Section 2 The liver sinusoid in acute liver injury 8. Drug-induced liver injury 9. Ischemia-reperfusion injury and liver regeneration 10. Acute bacterial and viral infections

Section 3 The liver sinusoid in chronic liver disease 11. NAFLD and NASH 12. Chronic viral infection 13. Alcoholic liver disease 14. Portal hypertension 15. Liver fibrosis 16. Acute on chronic liver failure 17. Liver cancer 18. Cholestatic diseases

Section 4 The liver sinusoid in other vascular diseases 19. Portal vein thrombosis 20. Sinusoidal obstructive syndrome 21. Budd Chiari syndrome

Section 5 Liver sinusoidal cells in the diagnosis and treatment of liver diseases 22. Role of liver sinusoidal endothelial cells 23. Role of Kupffer cells and other immune cells 24. Role of hepatic stellate cells