Proteases and Their Inhibitors in Cancer Metastasis

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account.
This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.

Contenu
Molecular Biology of the Plasminogen System: The Delicate Balance between Tissue Healing and Tissue Destruction.- Role of Serine Proteases and their Inhibitors in Tumor Growth and Angiogenesis.- The Gelatinases, MMP-2 and MMP-9-Implications for Invasion and Metastasis.- The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis.- Stromelysin-3, a Particular Member of the Matrix Metalloproteinase Family.- Membrane-Type Matrix Metalloproteinases.- 3D Structure and Drug Design.- Transcriptional Control of Proteases.- Tissue Inhibitors of Metalloproteinases in Cancer.- Clinical Aspects of Matrix Metalloproteinases.- Tissue Models to Study Tumor-Stroma Interactions.- Mammalian Heparanase: Molecular Properties, Inhibition and Involvement in Tumor Metastasis and Angiogenesis.