Notch Signaling in Embryology and Cancer

This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch's role in the development of the embryo to the Notch signaling pathway's role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch's role in senescence, the regulation of Notch signaling by microRNAs, Notch's role in the microbiome, diet and its influence on Notch signaling and more.

Taken as a whole, with its companion books Molecular Biology of Notch Signaling and Notch Signaling in Cancer this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

Presents content in a logical and coherent structure, enabling the reader to readily access relevant information Edited by renowned experts on Notch and Notch Signaling with contributions from internationally-recognized researchers Timely and urgently needed update in a rapidly developing field

Auteur

Sandra and Jörg Reichrath are working at the Clinic for Dermatology; Allergology and Venerology of the Saarland University Hospital in Homburg/Saar. Germany. Main research interests include photobiology, carcinogenesis of skin cancer (with a special interest for the role of ultraviolet radiation, Notch and p53), and the relevance of the vitamin D endocrine system for health and disease. Sandra received her academic degrees (Dipl. Biol. and Dr. rer. nat.) from the Albert-Ludwigs-Universität (Freiburg, Germany) and from Saarland University (Saarbrücken/Homburg, Germany), respectively. Jörg received his academic degrees (Dr. med., venia legendi) from Saarland University (Saarbrücken/Homburg, Germany). He has been awarded numerous prizes including the Arnold-Rikli-Prize in 2006.

Contenu

Notch signalling and embryology: an introduction.- Notch signaling and embryonic development: an ancient friend, revisited.- The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development.- Epigenetic regulation of Notch signaling during Drosophila development.- Regulation of proneural wave propagation through a combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion.- A nucleolar protein, Nepro, is essential for the maintenance of early neural stem cells and preimplantation embryos.- The role of Notch signaling in leg development in Drosophila melanogaster.- Notch pathway and inherited diseases: challenge and promise.- Index.