This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments. Expert authors describe new therapies that have led to significant improvements in patient function and survival.

Pathophysiology and therapy of pulmonary hypertension have had enormous developments over the past decade Discoveries of endothelin excess as well as prostacyclin and nitric oxide deficiency have led to important therapeutic insights Identification of genes associated with pulmonary hypertension has begun to open the door to pathophysiologic insights Expert authors describe new therapies that have led to significant improvements in patient function, qualtiy of life, and survival

Contenu
Historical Perspective: A Century of Primary (Idiopathic) Pulmonary Hypertension.- Classification of Pulmonary Hypertension.- Diagnostic Approach to Pulmonary Arterial Hypertension.- Pathophysiology of Pulmonary Arterial Hypertension.- Pulmonary Hypertension Genes.- The Right Ventricle in Pulmonary Hypertension.- Congenital Heart Disease Associated with Pulmonary Arterial Hypertension.- Connective Tissue Disease Associated Pulmonary Hypertension.- Pulmonary Hypertension Associated with HIV, Liver Disease, Sarcoidosis, and Sickle Cell Disease.- Chronic Thromboembolic Pulmonary Hypertension.- General Therapeutic Approach and Traditional Therapies.- Prostacyclin Therapy for Pulmonary Arterial Hypertension.- Endothelin and Its Blockade in Pulmonary Arterial Hypertension.- PDE5 Inhibitors and the cGMP Pathway in Pulmonary Arterial Hypertension.- Statins for Treatment of Pulmonary Hypertension.- Transitions and Combination Therapy for Pulmonary Arterial Hypertension.- Acute Right Ventricular Dysfunction: Focus on Acute Cor Pulmonale.- Lung Transplantation and Atrial Septostomy for Pulmonary Arterial Hypertension.- New Directions in Pulmonary Hypertension Therapy.