"A first-rate method book...[The authors] are highly skilled scientists with many years of experience in epilepsy."- Mannfred A. Hollinger, Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, Davis

Auteur
Steven L. Peterson

Texte du rabat

Methods in Epilepsy Research is a guide for the reproduction of well characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. It also considers the appropriate application of reductionist techniques to experimental models of epilepsy. TOC:Electroshock. - Chemoconvulsions. - Kindling. - Brain Slice Preparation for Epilepsy Research. - In Vivo Massed Trial Stimulations. - Audiogenic Seizures in the Mouse and Genetically Epilepsy-Prone Rat. - Focal Seizures. - Evaluation of Behavioural Cognitive Deficits Associated With Antiepileptic Drugs. - Diurnal and Circadian Influences on Seizure Response. - Microdialysis Techniques of Epilepsy Research. - Automated EEG Analyses. - Status Epilepticus. - Focal Microinfusions and Consideration of Neuronal Networks in Epilepsy Research. - Genetic Models of Epilepsy.

Résumé
Describes various experimental models of epilepsy. This book studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which various molecular biology techniques can be applied.

Contenu

Electroshock, Chemoconvulsants, The Kindling Model of Temporal Lobe Epilepsy, Rapid Kindling: Behavioral and Electrographic, Experimental Models of Status Epilepticus, Audiogenic Seizures in Mice and Rats, Models of Focal Epilepsy in Rodents, Evaluation of Associated Behavioral and Cognitive Deficits in Anticonvulsant Drug Testing, Gene Targeting Models of Epilepsy: Technical and Analytical Considerations, The Hippocampal Slice Preparation, Microdialysis Techniques for Epilepsy Research, Methodologies for Determining Rhythmic Expression of Seizures.