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The Synthetic Organic Chemist's Companion

  • Couverture cartonnée
  • 208 Nombre de pages
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The Organic Chemists' Companion provides a practical, hands-on resource for students and practitioners of organic synthesis. The b... Lire la suite
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The Organic Chemists' Companion provides a practical, hands-on resource for students and practitioners of organic synthesis. The book presents the fundamentals and guides the reader through the entire process of organic synthesis.

Michael C. Pirrung, PhD, is a Professor of Chemistry and UC Presidential Chair at the University of California-Riverside. He received his PhD in organic chemistry at UC-Berkeley in 1980 under the direction of Clayton Heathcock and did postdoctoral work with Gilbert Stork at Columbia as an NSF postdoctoral fellow. He is a member and is on the Steering Committee for the Chemical Genomics IGERT Program and has served on the Editorial Boards of the Journal of Combinatorial Chemistry, QSAR and Combinatorial Science, and Chemistry and Biology.

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A practical, hands-on guide that belongs in every organic chemistry lab A unique reference that consolidates essential information in a practical, user-friendly format, The Synthetic Organic Chemist's Companion provides a detailed description of how to perform synthetic reactions in real-world research settings, covering the most commonly used techniques. Packed with tips, data, and real-life examples, this handbook: * Is current, covering practical synthetic chemistry the way it is practiced in research labs today, and addressing topics such as SciFinder and related searching, microwave chemistry, ultrasonication, and solvent purification without distillation * Is comprehensive, taking the experimenter from the initial commercial compound and literature search all the way through to the full characterization of the pure product * Is well organized, following the process that the chemist goes through, from initiating to completing a synthetic experiment * Features insider tips and tricks that experienced synthetic chemists know * Includes numerous illustrations, lists, tables, and charts, including a solvent selection chart that makes information instantly accessible * Covers handling and preparing reagents, gases, and solvents, specific details for small-scale reactions, conducting the reaction (including temperature control), following up the reaction (including evaporation, vacuum, and purification), and identifying the product (including spectroscopy) A thorough, accessible reference for organic chemists, laboratory technicians, or students, this guide merits a prominent place in every lab. It's also a great textbook for upper-level undergraduate and graduate students studying organic chemistry, medicine, pharmaceuticals, and polymers.

Preface. Acknowledgments. 1. Searching the Literature. 1.1. Commercial availability. 1.2. Literature preparations. 2. Reagents. 2.1. Short path distillation. 2.2. Ampules. 2.3. Reagent solutions. 2.4. Titration. 2.5. Reagent storage. 2.6. Subtle reagent variations. 2.7. Dangerous reagents. 2.8. Reagent properties. 3. Gases. 3.1. Lecture bottles. 3.2. Tanks or cylinders. 3.3. Gas safety. 4. Reactions on a Small Scale - 1-25 mmol. 4.1. Reaction flasks. 4.2. Stirring. 4.3. Glass joints. 4.4. Inert atmosphere. 4.5. Apparatus for addition. 4.6. Condensers. 4.7. Other equipment and considerations. 5. Temperature Control. 5.1. Heating. 5.2. Cooling. 6. Solvents. 6.1. Selection. 6.2. Purity. 6.3. Degassing. 6.4. Ammonia. 7. The Research Notebook. 8. Conducting the Reaction Itself. 8.1. Reagents supplied as dispersions. 8.2. Azeotropic drying. 8.3. Stoichiometry. 8.4. Syringe and inert atmosphere techniques. 8.5. General procedure for transfer of materials by syringe. 8.6. Addition. 8.7. Special techniques. 8.7.1.Water removal. 8.7.2.Reactions above atmospheric pressure. 8.7.3.Reagent gases. 8.7.4.Ultrasonication. 8.8 Quenching . 8.9. Specialized reagents. 8.9.1. Diazomethane. 8.9.2. Lithium aluminum hydride. 8.9.3.Hydrogen peroxide. 8.10. Reaction time vs. purification time. 9. Following the Reaction. 9.1. Thin layer chromatography (TLC). 9.1.1. Cutting glass TLC plates. 9.1.2. Spotting TLC plates. 9.1.3. Eluting TLC plates. 9.1.4. Visualizing TLC plates. 9.2. Gas chromatography (GC). 9.3. High pressure liquid chromatography (HPLC). 9.4. NMR spectroscopy. 10. Working Up Reactions. 10.1. Solvent extracation. 10.2. Drying organic solutions. 10.3. Specialized work-ups. 10.3.1. Reactions producing triphenylphosphine oxide. 10.3.2. Reactions involving boron compounds. 10.3.3. Reactions involving copper salts. 10.3.4. Reactions involving aluminum reagents. 10.3.5. Reactions involving tin reagents. 11. Evaporation. 12. Vacuum Systems. 12.1. Vacuum sources. 12.2. Vacuum manifolds. 12.3. Vacuum gauges. 13. Purification of Products. 13.1. Distillation. 13.2. Silica gel chromatography. 13.3. Flash column chromatography. 13.4. Gradients. 13.5. Special absorbents. 13.5.1. Triethylamine-treated silica gel. 13.5.2. Oxalic acid-coated silica gel. 13.5.3. Silver nitrate-impregnated silica gel. 13.5.4. Other sorbents. 13.6. Preparative gas chromatography. 14. Methods for Structure Elucidation. 14.1. Nuclear magnetic resonance spectroscopy. 14.2. Infrared spectroscopy (IR). 14.3. Ultravilolet spectroscopy (UV). 14.4. Combustion analysis. 14.5. Mass spectrometry. 14.6. Crystallography. 15. Cleaning Up After the Reaction. 16. Specific Examples. 16.1. The experimental. 16.2. The Org. Syn. Prep. 16.3. Comparison. 17. Strategies for Reaction Organization. Appendices. 1. NMR spectral data of common contaminants of organic reaction products. 2. Synthetic solvent selection chart. 3. Recipes for TLC stains. 4. Mixotropic series. 5. Stuck joints. 6. Acidities of organic functional groups. 7. Acidities of organic functional groups in DMSO. 8. Web resources for synthetic chemistry.

Informations sur le produit

Titre: The Synthetic Organic Chemist's Companion
Code EAN: 9780470107072
ISBN: 978-0-470-10707-2
Format: Couverture cartonnée
Editeur: John Wiley and Sons Ltd
Genre: Chimie
nombre de pages: 208
Poids: 298g
Taille: H229mm x B154mm x T12mm
Année: 2007
Auflage: 1. Auflage