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The Response of E. coli to the Biocide Polyhexamethylene Biguanide

  • Couverture cartonnée
  • 364 Nombre de pages
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Response of E. coli to PHMB Polyhexamethylene biguanide (PHMB) is a cationic surfactant commonly used as a biocide against a wide ... Lire la suite
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Description

Response of E. coli to PHMB Polyhexamethylene biguanide (PHMB) is a cationic surfactant commonly used as a biocide against a wide range of microorganisms in a variety of medical and industrial contexts. PHMB has bacteriostatic or bactericidal effects depending on concentration. Previously its action was thought to be caused by disruption of the outer and inner membranes. Transcriptional and protein profiles were generated for E. coli cells exposed to bacteriostatic levels of PHMB. Genes found to be altered in their expression were associated with outer, periplasmic and inner membrane functin and also cytoplasmic function. Crucially, the results showed the induction of members of the DNA and cytoplasmic protein damage responses, suggesting that effects of PHMB are not restricted to the cell envelope but also occur in the cytoplasm. PHMB was then shown to bind to nucleic acids in vitro in a highly cooperative manner and cause their precipitation. The dosage dependent effect observed in PHMB activity can be attributed, not only to the disruption of inner membrane, but also to the interaction with cytoplasmic nucleic acids.

Auteur

Mike Allen obtained a BSc in Medical Molecular Biology at Cardiff University in 2000, a PhD entitled The Response of E. coli to the Biocide Polyhexamethylene Biguanide in 2004. He is currently a Senior Scientist at Plymouth Marine Laboratory and undertakes research on marine viruses, biofuels and biotechnology.

Informations sur le produit

Titre: The Response of E. coli to the Biocide Polyhexamethylene Biguanide
Sous-titre: The molecular stress response to PHMB suggests interaction with nucleic acids is crucial for biocidal activity.
Auteur:
Code EAN: 9783838373874
ISBN: 3838373871
Format: Couverture cartonnée
nombre de pages: 364
Poids: 558g
Taille: H220mm x B150mm x T22mm
Parution: 01.06.2010
Année: 2010

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