Human Ageing

Auteur

Michael A. Singer is author of the #1 New York Times bestseller, The Untethered Soul, and the New York Times bestseller, The Surrender Experiment, which have both been published worldwide. He had a deep inner awakening in 1971 while working on his doctorate in economics, and went into seclusion to focus on yoga and meditation. In 1975, he founded Temple of the Universe, a now long-established yoga and meditation center where people of any religion or set of beliefs can come together to experience inner peace. He is also creator of a leading-edge software package that transformed the medical practice management industry, and founding CEO of a billion-dollar public company whose achievements are archived in the Smithsonian Institution. Along with his more than four decades of spiritual teaching, Singer has made major contributions in the areas of business, education, health care, and environmental protection. He previously authored two books on the integration of Eastern and Western philosophy: The Search for Truth and Three Essays on Universal Law. Visit www.untetheredsoul.com for more information.

Texte du rabat

Human Ageing: A Unique Experience explores the biology of human ageing focusing on the individual. The book begins with the premature ageing disorder Hutchinson-Gilford Progeria syndrome and spins a web of interconnected biological domains involving lamins, telomeres, alternative splicing, genetics, epigenetics, and molecular clocks. The profound influence of culture is explored since cultural inheritance and genetic inheritance are the two intertwined processes driving human evolution. An empirical framework is developed to describe human ageing at the individual level and the implications of this framework on the whole concept of diseases are discussed.

Contenu

Biology of Ageing: Lamins; Alternative Splicing; Telomeres; Wnt Signaling; mTOR Pathway; Molecular Clocks; Ageing and Environmental Cues i.e. Experiences: Regulation of Gene Expression; Epigenetics and Ageing; Immediate Early Genes; Effects of Specific Environmental Cues; Domestication: Domestication Process; The Dog; Diseases in Dogs; Social Context and Culture: Gene-Culture Co-Evolution; Society; Culture and Ageing; Framework of Human Ageing: Developmental Programs; Biological Processes; Cellular Senescence; Environmental Cues (Experiences); Niche Construction Practices; Disease Construct and Ageing: History of Disease Construct; Personalized Medicine; Disease or Ageing?;