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MHC Volume 1

  • Couverture cartonnée
  • 236 Nombre de pages
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In the PRACTICAL APPROACH series, Volume 1 of a two-volume introduction, for immunology laboratories, to biochemical and genetic t... Lire la suite
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Description

In the PRACTICAL APPROACH series, Volume 1 of a two-volume introduction, for immunology laboratories, to biochemical and genetic techniques for the study of the structure of major histocompatibility complex proteins and their function as antigen presenting molecules.

Auteur

Dr Nelson Fernandez, Dept of Biological and Chemical Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK. Tel: 01206 873330. Fax: 01206 872592. Email: nelson@essex.ac.uk Dr Geoff Butcher, Babraham Institute, Babraham, Cambridge, UK



Texte du rabat

The major histocompatibility complex is the subject of much research in the immunology field. There is a great deal of interest in MHC proteins and their function as antigen presenting molecules, and many immunology laboratories are investigating biochemical and genetic techniques to study these molecules. The identification of peptide transporter genes and the elution of peptides from MHC molecules illustrate how rapidly our understanding of the MHC locus has advanced. This volume brings together the technologies which make these advances possible. It explains in detail the process such as peptide translocation into the ER, the application of mass spectrometry to the analysis of peptides bound to MHC, and signal detection via MHC class II molecules, which lead to either activation or cell death. The book is a comprehensive and thorough guide to the field of MHC research that graduates, post doctoral researchers, and academic staff and clinicians will find invaluable.



Contenu

1. Isolation and functional properties of antigen presenting cells; 2. Labelling methods for analysis of Class II MHC endocytosis and peptide turnover; 3. Methods for detecting signalling via MHC class II molecules which can lead to either activation or programmed cell death; 4. Peptide translocation into the ER; 5. The 20S proteasome and antigen presentation; 6. Analysis of MHC class II specific T cell clones; 7. Methods to study the role of the MHC in NK toxicity; 8. The interaction of superantigens with MHC class II molecules; 9. Methods for the generation of T cell clones and epithelial cell lines from excised human biopsies or needle aspirates; 10. The application of mass spectrometry to the analysis of peptides bound to MHC; 11. The molecular basis of alloreactivity; 12. Elution and analysis of peptide pools from MHC class I molecules

Informations sur le produit

Titre: MHC Volume 1
Sous-titre: A Practical Approach
Éditeur:
Code EAN: 9780199635535
ISBN: 978-0-19-963553-5
Format: Couverture cartonnée
Editeur: Oxford University Press
Genre: Médecine
nombre de pages: 236
Poids: 422g
Taille: H235mm x B157mm x T14mm
Année: 1997

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