MFG-E8 and Inflammation

After the discovery of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) about two decades ago, a new era of delineating its potential beneficial role in several inflammatory diseases has begun to spout from the bench to translational research. In MFG-E8 and Inflammation, the editor and contributors have gathered a remarkable collection covering novel discoveries on the rapidly growing field of MFG-E8 and Inflammation which includes not only the findings from their individual lobotomies, but also from a host of pioneering researchers of this field. MFG-E8 and Inflammation starts by describing the origin, structure, expression, functions and regulation of MFG-E8, and then continues thoughtfully exploring its potentiality as a marker for apoptotic, stressed and activated cells. The topics cover the cellular and physiological function of MFG-E8, especially its role in efficient phagocytosis of apoptotic cells, intestinal barrier function, blood cell homeostasis and coagulation, and in the maintenance of the intact vascular system. The role of MFG-E8 in macrophages, neutrophils, lymphocytes, dendritic cells, platelets, as well as non-hematopoietic cells is adequately described in the book. The chapters also contain several lucid discussions on the recent discoveries of the roles of MFG-E8 in the autoimmune diseases, sepsis, tissue ischemia-reperfusion, hemorrhage, inflammatory bowel diseases, acute lung injury, asthma, lung fibrosis, stroke, prion diseases and Alzheimer's diseases with the potential focus on elucidating novel mechanistic pathways. MFG-E8 and Inflammation is an indispensable resource for scientists and clinical researchers working on fundamental or applied aspects of MFG-E8 pathobiology. This book explores, dissects and reviews several noteworthy findings and striking future perspectives which not only rewrite the disease pathophysiology, but also update our understanding towards attaining novel therapeutic potentials against variousinflammatory diseases.

Simple and easy illustration of the complex network of innate immune system in human diseases A number of novel mechanistic aspects highlighting MFG-E8's therapeutic potential Includes several animal models relevant to critical care medicine and inflammatory diseases

Auteur
Ping Wang, MD, is the Vice Chairman for Research at the Department of Surgery, and Professor of Surgery and Molecular Medicine at Hofstra North Shore-LIJ School of Medicine. He is also the Head of the Center for Translational Research at the Feinstein Institute for Medical Research. Previously, Dr. Wang has held positions of Associate Professor of Surgery at Brown University School of Medicine and Professor of Surgery, Pathology, Physiology and Biophysics at University of Alabama at Birmingham (UAB), as well as Professor of Surgery at Albert Einstein College of Medicine. His laboratory has been continually funded by the NIH since 1995. Dr. Wang has published over 300 peer-reviewed articles in the field of inflammation research.

Contenu

Preface.- MFG-E8: origin, structure, expression, functions and regulation.- MFG-E8 as a marker for apoptotic, stressed and activated cells.- Role of MFG-E8 in protection of intestinal epithelial barrier function and attenuation of intestinal inflammation.- MFG-E8 in the blood cell homeostasis and coagulation.- MFG-E8 in the vascular system.- Autoimmune diseases and the role of MFG-E8.- Novel therapeutic for systemic inflammation: role of MFG-E8.- Expression and function of MFG-E8 during intestinal inflammation.- MFG-E8 and acute lung injury.- Role of MFG-E8 in the brain. Index.