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Metronomic Chemotherapy

  • Livre Relié
  • 295 Nombre de pages
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This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administer... Lire la suite
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Description

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Texte du rabat

At the end of the 1990s, researchers began to investigate the antiangiogenic activity of frequent administration of low-dose chemotherapeutic drugs, as a mechanism potentially contributing to their antineoplastic activity in vivo. During the past decade, a number of studies have shown that such metronomic chemotherapy has preclinical and clinical activity that may be ascribed to various mechanisms of action, including the inhibition of angiogenesis and the induction of an increase in the immunological response. Numerous phase I and phase II clinical trials have investigated the use of metronomic chemotherapy in different tumors and phase III clinical trials are currently ongoing. This book analyzes all aspects of this new therapeutic approach and its possible future development. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug and on the potential role of combination agents such as tyrosine kinase inhibitors and monoclonal antibodies are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacoeconomics and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.



Contenu

Part I: Pharmacological bases of metronomic chemotherapy: The metronomic concept.- Antiangiogenic effects of metronomic chemotherapy.- Effects of metronomic chemotherapy on immunity.- Other proposed mechanism of action of metronomic chemotherapy. Part II: Preclinical studies of metronomic chemotherapy: Alkylating agents.- Camptothecins.- Fluoropyrimidines.- Taxanes.- Vinca alkaloids.- Anthracyclines.- Other drugs.- Part III. Drugs combined with metronomic chemotherapy in preclinical studies: Tyrosine kinase inhibitors.- Monoclonal antibodies.- Tumor vaccines.- Other drugs. Part IV. Clinical activity of metronomic chemotherapy: Breast cancers.- Prostate cancers.- Gastrointestinal cancers.- CNS cancers.- Pediatric malignancies.- Sarcomas.- Hematological cancers.- Liver cancers.- Gynecologic Cancers.- Lung cancers.- Other cancers. Part V: Clinical Pharmacology of metronomic chemotherapy: Pharmacokinetics of metronomic chemotherapy.- Pharmacodynamics of metronomic chemotherapy.- Pharmacogenetics of metronomic chemotherapy.- Pharmacoeconomics of metronomic chemotherapy and its social impact.- Adverse drug reactions of metronomic chemotherapy. Part VI: Metronomic chemotherapy in veterinarian clinic: Clinical studies of metronomic chemotherapy alone.-Clinical studies of metronomic chemotherapy and other drugs.

Informations sur le produit

Titre: Metronomic Chemotherapy
Éditeur:
Code EAN: 9783662436035
ISBN: 978-3-662-43603-5
Format: Livre Relié
Genre: Médecine
nombre de pages: 295
Poids: 654g
Taille: H18mm x B243mm x T162mm
Année: 2014
Auflage: 2014

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