Methods of Pesticide Exposure Assessment

This book is a summary of the presentations and discussions at the Workshop on Methods of Pesticide Exposure Assessment held in Ottawa, Canada, on October 5-8, 1993. The event was a joint effort of Health Canada and the North Atlantic Treaty Organisation and was officially supported by the United States Environmental Agency and the Organisation for Economic Co-operation and Development (OECD). The goal of the workshop was to examine current issues in the field of pesticide exposure assessment with the aim of reaching an internationally harmonized approach to methods of exposure assessment. With regulatory agencies of OECD Member countries moving towards the harmonization of data requirements, it was timely and beneficial to bring together international experts in the field of pesticide exposure assessment to discuss current issues. Approximately 60 delegates and 20 observers participated, including individuals from 15 different countries representing academia, government, industry and international organizations. A guidance document on methods of pesticide exposure assessment was presented as a means to achieving the goal of international for critique and discussion harmonization. After extensive discussion, the workshop delegates agreed in principle to procedures for revising the guidance document. Following revision and further review by a designated peer review group, the revised document will be submitted to the OECD for consideration as a draft OECD Guidance Document on pesticide exposure assessment methods. Both the revised and original documents are included in these proceedings.

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Proceedings of a workshop held in Ottawa, Ontario, Canada, October 5-8, 1993

Résumé
Proceedings of a workshop held in Ottawa, Ontario, Canada, October 5-8, 1993

Contenu
Pesticide Exposure Assessment: Past, Present, and Future.- Pesticide Exposure and Re-entry in Agriculture.- Session One Guidance Document for the Conduct of Field Studies to Evaluate the Exposure of Operators, Workers, and Bystanders to Pesticides.- The Conduct of Field Studies to Evaluate the Exposure of Operators, Workers, and Bystanders to Pesticides.- Study Design Considerations for Occupational Pesticide Exposure Assessment.- Guidance Document: Quality Assurance/Quality Control.- Guidance Document: A Critique of Pharmacokinetics and Biological Monitoring.- Passive Dosimetry: Possibilities for Use in Risk Assessment (Critique on the Guidance Document with Respect to Passive Dosimetry).- Critique of the Guidance Document and Guidelines for the Conduct of Field Studies to Evaluate the Exposure of Operators, Workers, and Bystanders.- Session Two Pesticide Exposure Databases.- The Pesticide Handlers Exposure Database (PHED): Regulatory Overview.- A European Operator Exposure Database.- A Comparison of the Pesticide Handlers Exposure Database (PHED) and the European Predictive Operator Exposure Model (EUROPOEM) Database.- Session Three The Tier Approach.- Pesticide Exposure: Overview of the Tier Approach.- The Tier Approach to Pesticide Exposure Assessment: Are We There?.- Quantitative Assessment of Human Pesticide Exposure: Some Defaults and Assumptions.- Session Four Biomarkers of Exposure.- Biologic Markers: Monitoring Populations Exposed to Pesticides.- Using Immunochemical Methods to Analyze for Biomarkers of Exposure.- The Use of Biomarkers in the Epidemiological Surveillance of Pesticide Workers.- Biomarker Testing for the Assessment of Populations Exposed to Hazardous Chemicals.- Appendices.- Revised Guidance Document for the Conduct ofField Studies of Exposure to Pesticides in Use.- Workshop Participants.