Bienvenue chez nous!
Logo Ex Libris

Methods for the Discovery and Characterization of G Protein-Coupled Receptors

  • Couverture cartonnée
  • 444 Nombre de pages
(0) Donner la première évaluation
Évaluations
(0)
(0)
(0)
(0)
(0)
Afficher toutes les évaluations
This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled recep... Lire la suite
CHF 194.00
Impression sur demande - l'exemplaire sera recherché pour vous.

Description

This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled receptors (GPCRs) which, in many cases, can be used directly to design experiments for the reader's particular GPCR of interest.

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In Methods for the Discovery and Characterization of G Protein-Coupled Receptors , experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader's particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors. Chapters also feature an important section called "Future Directions" which gives the reader an insight into advances soon to be realized in each area. Written for the popular Neuromethods series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Methods for the Discovery and Characterization of G Protein-Coupled Receptors serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors.

Résumé
From the reviews: "Methods for the Discovery and Characterization of G Protein-Coupled Receptors is an excellent reference text for anyone concerned with the dynamic life of GPCRs in living tissues. The book is suitably organized to cater to a wide audience, and the material is presented in a logical framework to permit understanding of major concepts by a novice. ... This would be a particularly valuable book for any structural biologist looking to build complexity into their experimental system to account for in vivo phenomena." (Michelle O'Malley, ChemBioChem, Vol. 13 (6), April, 2012)

Contenu

Part I: The G Protein-Coupled Receptor in the Genome

1. In Silico Identification of Novel G Protein-Coupled Receptors

Matthew N. Davies, David E. Gloriam, and Darren R. Flower

2. Alternative Pre-mRNA Splicing of G Protein-Coupled Receptors

Ying-Xian Pan, Steven Grinnell, and Gavril W. Pasternak

3. Detecting Polymorphisms in G Protein-Coupled Receptor Genes

Dmitri Proudnikov, Vadim Yuferov, and Mary Jeanne Kreek

4. Regulation of the Transcription of G Protein-Coupled Receptor Genes

Cheol Kyu Hwang, Ping-Yee Law, Li-Na Wei, and Horace H. Loh

5. Deciphering the Evolution of G Protein-Coupled Receptors in Vertebrates

Craig W. Stevens

Part II: The Trafficking of G Protein-Coupled Receptors

6. A New Approach to Visualize Endogenously Expressed G Protein-Coupled Receptors in Tissues and Living Cells

Brigitte L Kieffer and Grégory Scherrer

7. Post-Translational Regulation of G Protein-Coupled Receptors

Yu Qiu and Ping-Yee Law

8. Discovering G Protein-Coupled Receptor Motifs Mediating Export from the Endoplasmic Reticulum

Chunmin Dong and Guangyu Wu

9. Identifying G Protein-Coupled Receptor Escorts, Chaperones, and Intracellular Tethers Regulating Receptor Density at the Cell Surface

Stefano Marullo, Liliana Pardo Lopez, and Lamia Achour

10. A Novel Method for Determining the Kinetics of G Protein-Coupled Receptor Plasma Membrane Expression

Gregory W. Sawyer

Part III: The G Protein-Coupled Receptor on the Membrane

11. Characterizing the Pharmacology of G Protein-Coupled Receptors in Transfected Cell Lines

Kathryn A. Seely and Paul L. Prather

12. Novel Assay Technologies for the Discovery of G Protein-Coupled Receptor Drugs

Elisa Alvarez-Curto, Richard J. Ward, and Graeme Milligan

13. Discovering Cell-Type-Specific Patterns of G Protein-Coupled Receptor Phosphorylation

Kok Choi Kong, Andrew B. Tobin, and Adrian J. Butcher

14. Quantifying Allosteric Modulation of G Protein-Coupled Receptors

Frederick J. Ehlert and Hinako Suga

15. Experimental Designs for the Study of Receptor-Receptor Interactions

Dennis Paul

Part IV: The Regulation of G Protein-Coupled Receptors

16. Elucidating Agonist-Selective Mechanisms of G Protein-Coupled Receptor Desensitization

Chris P. Bailey and Eamonn Kelly

17. Detecting the Role of Arrestins in G-Protein Coupled Receptor Regulation

Laura M. Bohn and Patricia H. McDonald

18. Characterizing Molecular Mobility and Membrane Interactions of G Protein-Coupled Receptors

Vladana Vukojevic, Yu Ming, and Lars Terenius

19. Using RNA Interference to Downregulate G Protein-Coupled Receptors

Philippe Sarret, Louis Doré-Savard, Pascal Tétreault, Valérie Bégin-Lavallée, Marc-André Dansereau, and Nicolas Beaudet

20. Upregulating G Protein-Coupled Receptors with Receptor Antagonists

Ellen M. Unterwald

Informations sur le produit

Titre: Methods for the Discovery and Characterization of G Protein-Coupled Receptors
Éditeur:
Code EAN: 9781493958511
ISBN: 1493958518
Format: Couverture cartonnée
Genre: Médecine
nombre de pages: 444
Poids: 827g
Taille: H254mm x B178mm x T23mm
Année: 2016
Auflage: Softcover reprint of the original 1st ed. 2011.

Évaluations

Vue d’ensemble

Mes évaluations

Évaluez cet article