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Aquifex aeolicus sulfide: quinone oxidoreductase

  • Couverture cartonnée
  • 264 Nombre de pages
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The membrane associated flavoenzyme sulfide:quinone oxidoreductase (SQR) has been essential in the early stages of life on Earth, ... Lire la suite
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Description

The membrane associated flavoenzyme sulfide:quinone oxidoreductase (SQR) has been essential in the early stages of life on Earth, when the organisms had to survive high sulfide concentrations in the environment. Interestingly, it has been successively conserved in many species belonging to all three biological domains, and also in humans, revealing that its activity in the cells is still crucial nowadays. In particular, SQR is involved in sulfide detoxification, in sulfide-dependent respiration and photosynthesis, in heavy metal tolerance and in the regulation of sulfide homeostasis in higher eukaryotes, where sulfide has recently been discovered to act as a neurotransmitter. However, despite its high microbiological and medical relevance, SQR had remained poorly characterized until now, so the understanding of its function was limited. This book describes the SQR from the hyperthermophilic bacterium Aquifex aeolicus in a detailed structural, biochemical and functional perspective, thereby offering for the first time a deep insight into its intriguing but complicated enzymatic reaction.

Auteur

Marco Marcia obtained his MSc degree in Pharmaceutical Chemistry and Technology with Prof. G. Capranico at Bologna University in 2005. He continued his studies with Prof. H. Michel (Max Planck Institute of Biophysics, Frankfurt) and obtained his PhD degree at Frankfurt University in 2010. He is now a Postdoctoral Associate at Yale University.

Informations sur le produit

Titre: Aquifex aeolicus sulfide: quinone oxidoreductase
Sous-titre: Structural and functional characterization of a membrane-bound flavoenzyme involved in sulfide detoxification and respiration
Auteur:
Code EAN: 9783838122052
ISBN: 978-3-8381-2205-2
Format: Couverture cartonnée
Genre: Biologie
nombre de pages: 264
Poids: 409g
Taille: H220mm x B150mm x T16mm
Année: 2010