Applied Epigenomic Epidemiology Essentials

Auteur

Laurens Holmes, Jr was the former Head of the Epidemiology Laboratory at the Nemours Center for Childhood Cancer Research, Wilmington and former Professor of Molecular Epidemiology and Clinical Trials at University of Delaware, USA. He is currently the Director of the Graduate Public Health Program, Delaware State University, Dover, USA.

Résumé
This applied clinical medicine and public health text introduces the fundamental concepts in epidemiological investigation and demonstrates how to integrate emerging research on epigenomics into practice.

Contenu

Section ONE Genomic, Epigenomic and Epigenomic Epidemiology Implication in Clinical Medicine and Public Health. 1.Introductory Epigenomic Epidemiology: Basic Concepts and Application. 2.Public Health, Epidemiology and Translational Epigenomic Epidemiology Perspective. 3.Scientific Research Concept and Application: Public Health, Clinical Medicine and Epigenomic Epidemiology Studies. 4.Disease Ascertainment- Diagnostic and Screening Test. 5.Epigenomic Epidemiology: Disease Association, Etiology, Prognosis and outcomes. Section TWO Epidemiologic Designs, Conduct, Measures of Effect and Confounding. 6.Measures of Disease Occurrence and Effect or Association. 7.Ecologic Design. 8.Cross-sectional study Design (non-experimental). 9.Case-Control (Comparison/non-Case) Design. 10.Cohort Designs: Prospective, Retrospective, Ambi-directional. 11.Human Experimental Design Clinical Trials. 12.Epidemiologic Causal Inference: Causality Web, Meta-Analysis, Quantitative Evidence Synthesis (QES). Section THREE Laboratory Techniques and Epigenomic Mechanistic Process in Epidemiologic Principles, Concept and Application. 13.Epigenomic Laboratory Procedures: Mechanistic process and Techniques. 14.Epigenomic Studies Perspective: Malignant Neoplasm & Cardiovascular Disease (CVD). 15.Pediatric ALL: Aberrant Epigenomic Modulation. 16.Cardiovascular Disease (CVDs) : DNA Methylation of Candidate Genes (ACE II, IFN-, AGTR 1, CKG, ADD1, SCNN1B and TLR2) in Essential Hypertension.