Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

The authoritative reference to bone diseases and disorders of mineral metabolism, revised and updated

Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism.

The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. This vital resource:

• Provides the most accurate, up-to-date evidence-based information on basic and clinical bone science
• Includes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers
• Captures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics
• Presents a new companion website with useful supplementary materials at www.asbmrprimer.com

Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

Auteur

John P. Bilezikian is the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University. He is Chief Emeritus of the Division of Endocrinology and Vice-chair of the Department of Medicine for International Research and Education. He is also Director Emeritus of the Metabolic Bone Diseases Program at Columbia University Medical Center.

Contenu

Contributors xi Preface to the Ninth Edition of the Primer: John P. Bilezikian xxiv About ASBMR xxv President's Preface Michael J. Econs xxvi About the Companion Website xxvii Section I Molecular and Cellular Determinants of Bone Structure and Function 1 Section Editor Karen Lyons 1 Early Skeletal Morphogenesis in Embryonic Development 3 Yingzi Yang 2 Endochondral Ossification 12 Courtney M. Karner and Matthew J. Hilton 3 Local and Circulating Osteoprogenitor Cells and Lineages 20 Naomi Dirckx and Christa Maes 4 Osteoblasts Function, Development, and Regulation 31 Elizabeth W. Bradley, Jennifer J. Westendorf, Andre J. van Wijnen, and Amel Dudakovic 5 Osteocytes 38 Lynda F. Bonewald 6 Osteoclast Biology and Bone Resorption 46 Hiroshi Takayanagi 7 Signal Transduction Cascades Controlling Osteoblast Differentiation 54 David J.J. de Gorter, Gonzalo Sánchez-Duffhues, and Peter ten Dijke 8 The TGF-ß Superfamily in Bone Formation and Maintenance 60 Ce Shi and Yuji Mishina 9 Recent Developments in Understanding the Role of Wnt Signaling in Skeletal Development and Disease 68 Zhendong A. Zhong, Nicole J. Ethen, and Bart O. Williams 10 Mechanotransduction in Bone Formation and Maintenance 75 Whitney A. Bullock, Lilian I. Plotkin, Alexander G. Robling, and Fredrick M. Pavalko 11 The Composition of Bone 84 Adele L. Boskey and Pamela G. Robey 12 Assessment of Bone Mass, Structure, and Quality in Rodents 93 Jeffry S. Nyman and Deepak Vashishth 13 Skeletal Healing Cellular and Molecular Determinants 101 Alayna E. Loiselle and Michael J. Zuscik 14 Biomechanics of Fracture Healing 108 Elise F. Morgan, Amira I. Hussein, and Thomas A. Einhorn Section II Skeletal Physiology 115 Section Editor Ego Seeman 15 Human Fetal and Neonatal Bone Development 117 Tao Yang, Monica Grover, Kyu Sang Joeng, and Brendan Lee 16 Skeletal Growth a Major Determinant of Bone's Structural Diversity in Women and Men 123 Ego Seeman 17 Racial Differences in the Acquisition and Age-related Loss of Bone Strength 131 Shane A. Norris, Marcella D. Walker, Kate Ward, Lisa K. Micklesfield, and John M. Pettifor 18 Calcium, Vitamin D, and Other Nutrients During Growth 135 Tania Winzenberg and Graeme Jones 19 Mechanical Loading and the Developing Skeleton 141 Mark R. Forwood 20 Pregnancy and Lactation 147 Christopher S. Kovacs and Henry M. Kronenberg 21 Menopause and Age-related Bone Loss 155 Carlos M. Isales and Ego Seeman Section III Mineral Homeostasis 163 Section Editors David Goltzman and Harald Jüppner 22 Regulation of Calcium Homeostasis 165 Line Vautour and David Goltzman 23 Magnesium Homeostasis 173 Aliya Aziz Khan, Asiya Sbayi, and Karl Peter Schlingmann 24 Fetal Calcium Metabolism 179 Christopher S. Kovacs 25 FGF23 and the Regulation of Phosphorus Metabolism 187 Kenneth E. White and Michael J. Econs 26 Gonadal Steroids 194 Stavros C. Manolagas and Maria Schuller Almeida 27 Parathyroid Hormone 205 Thomas J. Gardella, Robert A. Nissenson, and Harald Jüppner 28 Parathyroid Hormone-Related Protein 212 John J. Wysolmerski and T. John Martin 29 Calcium-Sensing Receptor 221 Geoffrey N. Hendy 30 Vitamin D Production, Metabolism, Action, and Clinical Requirements 230 Daniel D. Bikle, John S. Adams, and Sylvia Christakos Section IV Investigation of Metabolic Bone Diseases 241 Section Editors Douglas C. Bauer and Klaus Engelke 31 Techniques of Bone Mass Measurement in Children with Risk Factors for Osteoporosis 243 Nicola J. Crabtree and Leanne M. Ward 32 Standard Techniques of Bone Mass Measurement in Adults 252 E. Michael Lewiecki, Paul D. Miller, and Nelson B. Watts 33 Advanced Techniques of Bone Mass Measurements and Strength in Adults 260 Kyle K. Nishiyama, Enrico Dall'Ara, and Klaus Engelke 34 Magnetic Resonance Imaging of Bone 272 Sharmila Majumdar 35 Trabecular Bone Score 277 Barbara C. Silva and William D. Leslie 36 Reference Point Indentation 287 Adolfo Diez-Perez and Joshua N. Farr 37 Biochemical Markers of Bone Turnover in Osteoporosis 293 Pawel Szulc, Douglas C. Bauer, and Richard Eastell 38 Scintigraphy and PET in Metabolic Bone Disease 302 Lorenzo Nardo, Paola A. Erba, and Benjamin L. Franc 39 Bone Histomorphometry in Clinical Practice 310 Robert R. Recker and Carolina Aguiar Moreira 40 Diagnosis and Classification of Vertebral Fracture 319 James F. Griffith and Harry K. Genant 41 FRAX Assessment of Fracture Risk 331 John A. Kanis, Eugene V. McCloskey, Nicholas C. Harvey, and William D. Leslie Section V Genetics of Bone 341 Section Editor Rajesh V. Thakker 42 Introduction to Genetics 343 Paul J. Newey, Michael P. Whyte, and Rajesh V. Thakker 43 Animal Models Genetic Manipulation 351 Karen Lyons 44 Animal Models Allelic Determinants for Bone Mineral Density 359 J. H. Duncan Bassett, Graham R. Williams, and Robert D. Blank 45 Transcriptional Profiling for Genetic Assessment 367 Aimy Sebastian and Gabriela G. Loots 46 Approaches to Genetic Testing 373 Christina Jacobsen, Yiping Shen, and Ingrid A. Holm 47 Human Genome-Wide Association Studies 378 Douglas P. Kiel, Emma L. Duncan, and Fernando Rivadeneira 48 Translational Genetics of Osteoporosis From Population Association to Individualized Assessment 385 Bich Tran, Jacqueline R. Center, and Tuan V. Nguyen Section VI Osteoporosis 393 Section Editors Paul D. Miller, Socrates E. Papapoulos, and Michael R. McClung 49 Osteoporosis an Overview 395 Michael R. McClung, Paul D. Miller, and Socrates E. Papapoulos 50 The Epidemiology of Osteoporotic Fractures 398 Nicholas C. Harvey, Elizabeth M. Curtis, Elaine M. Dennison, and Cyrus Cooper 51 Fracture Liaison Service 405 Piet Geusens, John A. Eisman, Andrea Singer, and Joop van den Bergh 52 Sex Steroids and the Pathogenesi…