Hiv-Associated Neurocognitive Disorders

Texte du rabat

HIV-Associated Neurocognitive Disorders (HAND) presents a complex and evolving challenge in the context of HIV-1 infection and treatment. This comprehensive volume dives into the clinical manifestations, molecular and cellular mechanisms, and therapeutic strategies underlying HAND and its associated comorbidities. This book brings together cutting-edge research and clinical insights, making it an essential resource for researchers, clinicians, and students engaged in HIV-related studies and neurocognitive research. This resource also aims to advance our understanding of HAND to contribute to the development of novel diagnostic tools and therapeutic interventions for improved patient outcomes.

Contenu

Foreword

Preface

1. An overview of the mechanisms of HIV-1 infection, latency, pathogenesis, and eradication strategies from the CNS

2. Central Nervous System Complications of Human Immunodeficiency Virus Infection

3. Health LIteracy in HIV-associated Neurocognitive Disorders

4. Neuroimaging insights into the CNS effects of HIV infection

5. Early and upstream subcellular organellar events associated with HAND

6. White matter loss and oligodendrocyte dysfunction in HAND

7. Pathogenesis of HIV-associated pain

8. Neuropathogenesis of HIV-associated neuropathic pain

9. Neuropathic Pain in HIV and the role of the Autophagy pathway

10. Host peripheral immune dynamics increase HIV-associated neurocognitive disorders incidence and progression

11. The role of immunometabolism in HIV associated depression and cognitive impairment

12. Role of extracellular viral regulatory proteins in neuropathogenesis

13. Role of inflammasomes in HIV-1 and drug abuse-mediated neuroinflammation

14. The Contribution of Myeloid Cells to HIV Neuropathogenesis

15. Immunophilin ligands modulate phagocytosis and viral replication in HIV-infected macrophages

16. Immunometabolic mechanisms of HIV-associated neurocognitive disorders and traumatic brain injury: Commonalities and contrasts between chronic and acute neurodegenerative pathologies

17. Endolysosome dysfunction in HAND

18. Evolving biomarkers for HIV-associated neurocognitive disorders (HAND)

19. Intracellular immunity against HIV infection

20. NeuroHIV and the Glymphatic System

21. The p75 neurotrophin receptor: emerging role in the pathogenesis of mature synapses in Human Immunodeficiency Virus-Associated Neurocognitive Disorders

22. The Role of HIV-Associated Neuroendocrine Dysfunction in HAND

23. Impact of SARS-CoV-2/COVID-19 on HIV-1-associated neurocognitive disorders

24. Molecular mechanisms of dopaminergic transmission in NeuroHIV

25. The effect of substance misuse on HIV persistence in the CNS: epidemiological, immunological, and molecular considerations

26. Extracellular vesicles in alcohol- and tobacco-induced neuroAIDS

27. NeuroHIV in the context of opioid use disorder: A complex and evolving relationship

28. Impairment of cholesterol homeostasis induced by Nef-containing extracellular vesicles as a factor in HAND pathogenesis

29. Long noncoding RNAs in immune response, viral infection, and opioid use

30. Using cross-species behavioral tools to determine mechanisms contributing to HIV associated neurological disorders and comorbid substance use

31. Therapeutic potential of Curcumin in treating HIV-1 associated neurocognitive disorders

32. Targeting the Endocannabinoid System in HAND

33. Predicting the effectiveness of combination treatment of Dolutegravir and Fluoxetine for Depressive disorders in HIV

34. ANTIRETROVIRAL THERAPY AND ITS CEREBRAL VASCULAR TOXICITY

35. Strategies for HIV-1 Elimination