Helicobacter pylori Infection and Immunity

The discovery and concept that Helicobacter pylori is associated with gastric disease including gastric cancer which is one of the most common and frequently lethal forms of malignancy, heralded a new and rapidly expanding field recognizing the emergence of many new pathogens and disease syndromes in clinical medicine, as well as basic infectious disease research. There is now an extensive and widely known literature of how H. pylori is involved in a wide variety of disease syn dromes. As summarized in the introductory chapter of this volume, many major advances have been made in diagnosis, both serologic and endoscopic in time of the involvement of this organism in patients with upper GI ailments as well as its presence in those who are not clinically ill. The Introduction describes the rapid development of understanding the role of this organism in disease. The basic bacteriology of H. pylori is then described in the second chapter. Diagnostic tests for detecting H. pylori infection is then highlighted, as well as the role of such infection in gastric cancer. Current knowledge concerning risk factors and peptic ulcer pathology associated with H. pylori is then described. Newer information concerning therapy of H. pylori infection and colonization is described in a subsequent chapter as well as one concerning the effects of anti biotics on H. pylori infection. The extensive literature on natural substances with anti-H.

Texte du rabat

Today there is overwhelming evidence that Helicobacter pylori is the major cause of chronic active gastritis and that it may further predispose to peptic ulcers, of which there are several thousand cases in the US each year. The most severe clinical outcomes of H. pylori infection are mucosa-associated lymphoid tissue lymphoma and gastric cancer. Because of these findings, the implications for cancer etiology are intriguing. This book, a volume in the Infectious Agents and Pathogenesis series, presents chapters by major researchers in the field, including Dr. Barry Marshall whose research was responsible for establishing the linking of gastric ulcers with the H. pylori bacterium.

Contenu

1. The Bacteriology of Helicobacter pylori.- 2. Diagnosis of Helicobacter pylori Infection.- 3. Helicobacter pylori Infection and Gastric Cancer.- 4. Risk Factors and Peptic Ulcer Pathology.- 5. Helicobacter pylori Eradication Therapy.- 6. Mechanisms of Antibiotic Resistance in Helicobacter pylori.- 7. Anti-Helicobacter pylori Activity of Natural Substances.- 8. Adherence of Helicobacter pylori to Gastric Cell.- 9. Helicobacter pyloric Molecular Mimicry and Autoimmunity.- 10. Apoptosis and the Pathogenesis of Helicobacter pylori Related Disease.- 11. Toxins, Travels and Tropisms: H. pylori and Host Cells.- 12. Role of Cytokines in Helicobacter pylori Infection.- 13. Animal Models for Helicobacter pylori.- 14. Mongolian Gerbils Model.- 15. Vaccine Development.