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Handbook of Neurotoxicology

  • Livre Relié
  • 688 Nombre de pages
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In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians-all acknowledged experts-review in d... Lire la suite
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Description

In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians-all acknowledged experts-review in depth the status of research in key areas of current neurotoxicologic interest and examine the latest methodologies for in vivo assessment of a wide spectrum of agents exhibiting neurotoxicologic properties. The first volume of the Handbook focuses on the biological effects of human-made neurotoxins, as well as those of natural origin, which so often provide valuable therapeutics and research reagents. Topics range from anticholinesterase insecticides and pesticides that target ion channels, to such metals as mercury, lead, zinc, and to the polytypic byproducts of combustion and industrial manufacture. The natural toxins discussed include those of microbial origin (microbial, marine, clostridial, and botulilinal neurotoxins), as well as those of animal origin (snake, spider, and scorpion venoms). The second volume concentrates on the biological effects of human-made toxins on the developing nervous system, reviews the neuronal impact of drugs of abuse, and provides state-of-the-art methods for the evaluation of the biological effects of neurotoxicants by both imaging and neurobehavioral assessment.

Neurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, lead, mercury, and the polytypic bypro ducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins of broadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentally by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor tunately, the environmental accumulation of some neurotoxic ants of anthropogenic ori gin, especially pesticides and metals, has resulted in incidents of human poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the result of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxic ants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

"Both volumes are laid out attractively...and contain much valuable information on the pharmacological aspects of neurotoxicology, as well as state-of-the-art methodology." Le Journal Canadien Des Sciences Neurologies

Texte du rabat
Neurotoxins-whether human-generated pollutants or natural products-have recently attracted growing scientific interest. In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians-all acknowledged experts-review in depth the status of research in key areas of current neurotoxicologic interest and examine the latest methodologies for in vivo assessment of a wide spectrum of agents exhibiting neurotoxicologic properties. This first volume of the Handbook focuses on the biological effects of human-made neurotoxins, as well as those of natural origin, which so often provide valuable therapeutics and research reagents. Topics range from anticholinesterase insecticides and pesticides that target ion channels, to such metals as mercury, lead, zinc, and to the polytypic byproducts of combustion and industrial manufacture. The natural toxins discussed include those of microbial origin (microbial, marine, clostridial, and botulilinal neurotoxins), as well as those of animal origin (snake, spider, and scorpion venoms). Volume II concentrates on the biological effects of human-made toxins on the developing nervous system, reviews the neuronal impact of drugs of abuse, and provides state-of-the-art methods for the evaluation of the biological effects of neurotoxicants by both imaging and neurobehavioral assessment. Up-to-date and timely, the Handbook of Neurotoxicology, Volumes I and II, not only affords today's biomedical and clinical investigators a full panoply of knowledge in all the critical areas of current neurotoxicologic interest, but also illuminates the latest methodologies for assessing the effects of a broad spectrum of significant neurotoxicological agents.

Contenu
I. Pesticides Marion Ehrich and Jeffrey R. Bloomquist, Section Editors Subsection A. Anticholinesterase Insecticides Acute Toxicities of Organophosphates and Carbamates Janice E. Chambers and Russell L. Carr Organophosphate-Induced Delayed Neuropathy Marion Ehrich and Bernard S. Jortner Nonesterase Actions of Anticholinesterase Insecticides Carey Pope and Jing Liu Subsection B. Pesticides that Target Ion Channels Agents Affecting Sodium Channels David M. Soderlund Agents Affecting Chloride Channels Jeffrey R. Bloomquist The Neonicotinoid Insecticides Larry P. Sheets Subsection C. Miscellaneous Pesticides with Action on the Nervous System Miscellaneous Pesticides with Action on the Nervous System Dennis Blodgett, Marion Ehrich, and Jeffrey R. Bloomquist II. Metals Tomás R. Guilarte, Section Editor Molecular Mechanisms of Low-Level Pb2+ Neurotoxicity Michelle K. Nihei and Tomás R. Guilarte Elucidation of the Zinc-Finger Motif as a Target for Heavy-Metal Perturbations Nasser H. Zawia and Morad Razmiafshari Blood-Brain Barrier and Blood-CSF Barrier in Metal-Induced Neurotoxicities Wei Zheng Manganese in Health and Disease: From Transport to Neurotoxicity Michael Aschner, James R. Connor, David C. Dorman, Elise A. Malecki, and Kent E. Vrana Aluminum Neurotoxicity Andrzej Szutowicz III. Natural Toxins of Microbial Origin David J. Adams and Daniel G. Baden, Section Editors Ecology of Microbial Neurotoxins Lyndon E. Llewellyn Biosynthesis of Important Marine Toxins of Microorganism Origins Yuzuru Shimizu Biological Assay and Detection Methods for Marine 'Shellfish' Toxins Neale R. Towers and Ian Garthwaite An Overview of Clostridial Neurotoxins MarkA. Poli and Frank J. Lebeda Molecular Mechanism of Action of Botulinal Neurotoxins and the Synaptic Remodeling They Induce In Vivo at the Skeletal Neuromuscular Junction Frédéric A. Meunier, Judit Herreros, Giampietro Schiavo, Bernard Poulain, and Jordi Molgó Marine Mammals as Sentinels of Environmental Biotoxins Vera L. Trainer The Epidemiology of Human Illnesses Associated with Harmful Algal Blooms Lora E. Fleming, Lorraine Backer, and Alan Rowan IV. Natural Toxins of Animal Origin Alan Harvey, Section Editor Snake Neurotoxins that Interact with Nicotinic Acetylcholine Receptors Denis Servent and André Ménez Presynaptic Phospholipase A2 Neurotoxins from Snake Venoms John B. Harris Dendrotoxins from Mamba Snakes J. Oliver Dolly and Giacinto Bagetta Neurotoxins from Spider Venoms Alfonso Grasso and Stefano Rufini Neurotoxins from Scorpion Venoms Marie-France Martin-Eauclaire Anthozoan Neurotoxins William R. Kem Nemertine Neurotoxins William R. Kem Secretagogue Activity of Trachynilysin, a Neurotoxic Protein Isolated from Stonefish (Synanceia trachynis) Venom Frédéric A. Meunier, Gilles Ouanounou, Cesar Mattei, Pascal Chameau, Cesare Colasante, Yuri A. Ushkaryov, J. Oliver Dolly, Arnold S. Kreger, and Jordi Molgó Neurotoxins of Cone Snail Venoms Robert Newcomb and George Miljanich

Informations sur le produit

Titre: Handbook of Neurotoxicology
Éditeur:
Code EAN: 9780896037953
ISBN: 0896037959
Format: Livre Relié
Editeur: Humana Press
Genre: Médecine
nombre de pages: 688
Poids: 1626g
Taille: H260mm x B183mm x T46mm
Année: 2001
Auflage: 2002