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Handbook of Copper Pharmacology and Toxicology

  • Couverture cartonnée
  • 628 Nombre de pages
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Although copper is an essential trace element necessary for the survival of organisms ranging from bacteria to mammals, it is also... Lire la suite
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Description

Although copper is an essential trace element necessary for the survival of organisms ranging from bacteria to mammals, it is also highly toxic and must be absorbed by the body in precisely orchestrated biological processes. In Handbook of Copper Pharmacology and Toxicology, Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general, and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases-Menkes and Wilson's diseases and occipital horn syndrome-as well as the role of copper in Parkinson's disease, prion disease, familial amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The elucidation of the precise mechanisms of copper trafficking, metabolism, and homeostasis will be of considerable importance in understanding the pathophysiology and treatment of such diseases.
Comprehensive and timely, the Handbook of Copper Pharmacology and Toxicology authoritatively provides researchers with all the up-to-date information needed to work productively in copper biology today.

"...biochemical and molecular researchers from around the globe have produced 35 chapters documenting the present state of knowledge in selected areas of copper pharmacology and toxicology. the state-of-the-art data provided will no doubt stimulate challenging research with this essential trace element required by organism ranging from bacteria to mammals." - Veterinary and Human Toxicology

"The book has excellent introductory chapters, and summarizes much recent research at the genetic and cellular levels." - Newsletter of the British Toxicological Society

"Dr. Massaro must be congratulated for editing this comprehensive book on copper. There are so many outstanding chapters in this compendium that highlighting any one of them should not detract from the others...this book is a treasure trove of references. The price of the book, though modest for this compendium would be justified for the Preface and the first chapter alone. This book is highly recommended. At the present time it has no equal." -International Journal of Toxicology

Résumé
Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases, Menkes and Wilson's diseases and occipital horn syndrome, as well as the role of copper in Parkinson's disease, prion disease, familial amytrophic lateral sclerosis (ALS), and Alzheimer's disease.

Contenu
Part I. Copper in Mammals Biochemistry and Molecular Biology of Copper in Mammals Maria C. Linder Part II. Copper Proteins Biochemistry of the Wilson's Disease Protein Svetlana Lutsenko, Ruslan Tsivkovskii, Matthew J. Cooper, Brian C. MacArthur, and Hans-Peter Bächinger Biologically Relevant Properties of Copper-Containing Proteins Analyzed by Means of Semiquantitative and Quantitative Theoretical Descriptors, Francesca De Rienzo, R. Razif Gabdoulline, Rebecca C. Wade, and M. Cristina Menziani Molecular Modeling and Dynamics of Copper Proteins Mattia Falconi and Alessandro Desideri The Prion Protein and Copper: What Is the Connection? Lesley R. Brown and David A. Harris Prion Protein: A Synaptic Cuproprotein David R. Brown Cytochrome-c Oxidase Shinya Yoshikawa The Fet3 Protein: A Multicopper Ferroxidase Essential to Iron Metabolism in Yeast Daniel J. Kosman Interaction of Copper-Binding Proteins from Enteroccus hirae Paul A. Cobine, Christopher E. Jones, Wasantha A. Wickramasinghe, Marc Solioz, and Charles T. Dameron Part III. Copper Transport Copper Uptake in Eukaryotic Cells Lisbeth Birk Møller and Nina Horn The Role of PINA in Copper Transport, Circadian Rhythms, and Wilson's Disease Jimo Borjigin, Xing Sun, and Michael M. Wang The Identification of Motifs Involved in the Intracellular Trafficking of the Menkes Disease Protein Michael J. Francis and Anthony P. Monaco Intracellular Copper Transport and ATP7B, the Wilson's Disease Protein Kunihiko Terada and Toshihiro Sugiyama A Multicopper Oxidase-Based Iron-Transport System in Yeast Jerry Kaplan Part IV. Molecular Pathogenesis of Diseases of Copper Metabolism Molecular Basis of Diseases of Copper Homeostasis Julian F. B. Mercer, David Kramer, andJames Camakaris Disturbances of Copper Homeostasis and Brain Function Giuseppe Rotilio, Maria Rosa Ciriolo, Maria Teresa Carri, and Luisa Rossi Role of Copper and Other Transition Metal Ions in the Pathogenesis of Parkinson's Disease, Prion Diseases, Familial Amytrophic Lateral Sclerosis and Alzheimer's Disease Gerd Multhaup, Hermann H. Dieter, Konrad Beyreuther, and Thomas A. Bayer Molecular Genetics and Clinical Aspects of Menkes Disease and Occipital Horn Syndrome Hiroko Kodama The Meaning of Alternative Transcripts of the Menkes Disease Gene Edward D. Harris, Manchi C. M. Reddy, and Sudeep Majumdar Expression Profiling in Menkes Disease Zeynep Tümer, Nina Horn, and Lars Riff Jensen Regulation by Copper of the Expression of Human Bis, a New Gene Involved in the Cellular Stress Response to Metals Maria Gabriella Pagliuca, Rosa Lerose, and Arturo Leone Non-Indian Childhood Cirrhosis: Using a Founder Population to Identify the Underlying Genetic Defect Cisca Wijmenga Part V. Copper Toxicity and Therapeutics Biological Effects of Chronic Copper Exposure Magdalena Araya, Mauricio González, Manuel Olivares, and Ricardo Uauy Copper Toxicity to Tight Junctions in the Human Intestinal Caco-2 Cell Line Simonetta Ferruzza, Yula Sambuy, Andrea Onetti-Muda, Fabio Nobili, and Maria Laura Scarino Cellular Responses to Copper in Aquatic Organisms: Importance of Oxidative Stress and Alteration of Signal Transduction Aldo Viarengo, Bruno Burlando, and Claudia Bolognesi Selective Removal of Copper Accumulating in the Form Bound to Metallothionein by Tetrathiomolybdate Kazuo T. Suzuki and Yasumitsu Ogra Control of Copper in Wilson's Disease and Diseases of Neovascularization, such as Cancer George J. Brewer Copper-Rich Metallothionein Polymers During the Development of

Informations sur le produit

Titre: Handbook of Copper Pharmacology and Toxicology
Éditeur:
Code EAN: 9781617372667
ISBN: 1617372668
Format: Couverture cartonnée
Editeur: Humana Press
Genre: Médecine
nombre de pages: 628
Poids: 1163g
Taille: H254mm x B178mm x T33mm
Année: 2010
Auflage: Softcover reprint of hardcover 1st ed. 2002