Handbook of Copper Pharmacology and Toxicology

Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases, Menkes and Wilson's diseases and occipital horn syndrome, as well as the role of copper in Parkinson's disease, prion disease, familial amytrophic lateral sclerosis (ALS), and Alzheimer's disease.

Includes supplementary material: sn.pub/extras

Texte du rabat
Although copper is an essential trace element necessary for the survival of organisms ranging from bacteria to mammals, it is also highly toxic and must be absorbed by the body in precisely orchestrated biological processes. In Handbook of Copper Pharmacology and Toxicology, Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general, and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases-Menkes and Wilson's diseases and occipital horn syndrome-as well as the role of copper in Parkinson's disease, prion disease, familial amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The elucidation of the precise mechanisms of copper trafficking, metabolism, and homeostasis will be of considerable importance in understanding the pathophysiology and treatment of such diseases.
Comprehensive and timely, the Handbook of Copper Pharmacology and Toxicology authoritatively provides researchers with all the up-to-date information needed to work productively in copper biology today.

Contenu
I. Copper in Mammals.- 1 Biochemistry and Molecular Biology of Copper in Mammals.- II. Copper Proteins.- 2 Biochemistry of the Wilson's Disease Protein.- 3 Biologically Relevant Properties of Copper-Containing Proteins Analyzed by Means of Semiquantitative and Quantitative Theoretical Descriptors.- 4 Molecular Modeling and Dynamics of Copper Proteins.- 5 The Prion Protein and Copper: What Is the Connection?.- 6 Prion Protein: A Synaptic Cuproprotein.- 7 Cytochrome-c Oxidase.- 8 The Fet3 Protein: A Multicopper Ferroxidase Essential to Iron Metabolism in Yeast.- 9 Interaction of Copper-Binding Proteins from Enterococcus hirae.- III. Copper Transport.- 10 Copper Uptake in Eukaryotic Cells.- 11 The Role of PINA in Copper Transport, Circadian Rhythms, and Wilson's Disease.- 12 The Identification of Motifs Involved in the Intracellular Trafficking of the Menkes Disease Protein.- 13 Intracellular Copper Transport and ATP7B, the Wilson's Disease Protein.- 14 A Multicopper Oxidase-Based Iron-Transport System in Yeast.- IV. Molecular Pathogenesis of Diseases of Copper Metabolism.- 15 Molecular Basis of Diseases of Copper Homeostasis.- 16 Disturbances of Copper Homeostasis and Brain Function.- 17 Role of Copper and Other Transition Metal Ions in the Pathogenesis of Parkinson's Disease, Prion Diseases, Familial Amytrophic Lateral Sclerosis and Alzheimer's Disease.- 18 Molecular Genetics and Clinical Aspects of Menkes Disease and Occipital Horn Syndrome.- 19 The Meaning of Alternative Transcripts of the Menkes Disease Gene.- 20 Expression Profiling in Menkes Disease.- 21 Regulation by Copper of the Expression of Human Bis, a New Gene Involved in the Cellular Stress Response to Metals.- 22 Non-Indian Childhood Cirrhosis: Using a Founder Population to Identify the UnderlyingGenetic Defect.- V. Copper Toxicity and Therapeutics.- 23 Biological Effects of Chronic Copper Exposure.- 24 Copper Toxicity to Tight Junctions in the Human Intestina Caco-2 Cell Line.- 25 Cellular Responses to Copper in Aquatic Organisms: Importance of Oxidative Stress and Alteration of Signal Transduction.- 26 Selective Removal of Copper Accumulating in the Form Bound to Metallothionein by Tetrathiomolybdate.- 27 Control of Copper in Wilson's Disease and Diseases of Neovascularization, such as Cancer.- 28 Copper-Rich Metallothionein Polymers During the Development of Fulminant Hepatitis in LEC Rats: Effect of D-Penicillamine.- VI. Copper Metabolism and Homeostasis.- 29 Sensory Protein Modification: A New Feature in Copper Balancing.- 30 Comparative Analysis of Copper and Iron Metabolism in Photosynthetic Eukaryotes vs Yeast and Mammals.- 31 Copper and the Morphological Development of Streptomyces.- 32 Molecular Hardware of Copper Homeostasis in Enterococcus hirae.- 33 Copper Homeostasis in Plants.- 34 The Role of Copper Ions in Regulating Methane Monooxygenases in Methanotrophs.- 35 Regulatory Responses to Copper Ions in Fungi.