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Stem cell-based therapy of ocular surface diseases

  • Couverture cartonnée
  • 84 Nombre de pages
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One emerging surgical strategy for restoring a normal corneal epithelial surface in patients with limbal stem cell (SC) deficiency... Lire la suite
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Description

One emerging surgical strategy for restoring a normal corneal epithelial surface in patients with limbal stem cell (SC) deficiency is transplantation of ex vivo expanded limbal epithelial SC which represents one of the few adult human SC therapies being currently employed. In unilaterally affected patients, this therapeutic approach commonly involves the harvest of a small limbal biopsy from the patient s contralateral healthy eye followed by cell expansion ex vivo and generation of an epithelial sheet on a transplantable carrier. Although successful restoration of the ocular surface occurs in the early postoperative period, the long-term outcome is less satisfactory, most probably due to depletion of limbal SC in culture. In this work an improved culture protocol was established for isolation, enrichment and preservation of limbal epithelial stem and progenitor cells within transplantable cultivated epithelial cell sheets. Furthermore, the work focused on the examination of hair follicles as an alternative autologous SC source and developement of a new more promising therapy for patients with bilateral limbal SC deficiency.

Auteur

Geboren am 31.01.1979 in Tarnów (Polen) 2000-2004 Studium der Biologie an der Friedrich-Alexander-Universität Erlangen-Nürnberg 2005 Diplomarbeit am Institut für Klinische und Molekulare Virologie der Friedrich-Alexander-Universität Erlangen-Nürnberg 2006-2009 Promotion in der Augenklinik der Friedrich-Alexander-Universität Erlangen Nürnberg

Informations sur le produit

Titre: Stem cell-based therapy of ocular surface diseases
Sous-titre: Novel approaches to expansion of adult epithelial stem cells in culture
Auteur:
Code EAN: 9783838113876
ISBN: 383811387X
Format: Couverture cartonnée
Genre: Médecine
nombre de pages: 84
Poids: 142g
Taille: H220mm x B150mm x T5mm
Année: 2015

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