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Risk Assessment of Phytochemicals in Food

  • Couverture cartonnée
  • 476 Nombre de pages
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Phytochemicals are non-nutritive plant chemicals that protect us and prevent us from diseases. There are thousands of known phytoc... Lire la suite
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Phytochemicals are non-nutritive plant chemicals that protect us and prevent us from diseases. There are thousands of known phytochemicals, e.g. in tomatoes, soy and in fruits. While these are known helpful antioxidants, their potential toxicity is essential for identifying any risks for humans.

Providing the scientific background on the risk and safety assessment of toxicity in phytochemicals in everyday food, this monograph contains the pros and cons of 20 testing methods, with comments by the internationally acknowledged and independent DFG Senate Commission on Food Safety.
Supplemented by 40 poster contributions on phytochemicals and their effects.

Vorwort/Preface I BERICHT UND SCHLUSSFOLRGERUNGEN II REPORT AND CONCLUSIONS III CONTRIBUTIONS Visions on toxicity testing in the 21st century Safety assessment of botanicals and botanical preparations used as ingredients in food supplements In silico toxicology screening of the rodent carcinogenic potential of phytochemicals using QSAR analysis Testing compuational toxicology models with phytochemicals In silico models to establish level of safety concern in absence of sufficient toxicological data In silico mehtods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole; implications for risk assessment In vitro models for carcinogenicity testing - reality or fantasy? Carcinogen specific expression profiling: prediction of carcinogenic potential? Safety and biological efficacy testing of phytochemicals: an industry approach Metabolite profiling in rat plasma as a potential new tool for the assessment of chemically induced toxicity Profiling techniques in nutrition and food research The complex links between dietary phytochemicals and human health deciphered by metabolomics Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology The Japanese toxicogenomics project: application of toxicogenomics Toxicology and risk assessment of coumarin: focus on human data Risk from furocoumarins in food? An exposure assessment Transcriptome analysis in benefit-risk assessment of micronutrients and bioactive food components Colorectal and prostate cancer: The role of candidate genes in nutritional pathways Glucosinolates: DNA adduct formation in vivo and mutagenicity in vitro Defense mechanisms against toxic phytochemicals in the diet of domestic animals POSTERS Coumarin risk assessment: Lessons from human data Coffee and coffee compounds are effective antioxidants in human cells and in vivo Studying absorption, distribution, metabolism, and excretion of a complex extract Polyphenolic apple extracts and their constituents modulate DNA strand breaks and oxidation damage in human colon carcinoma cells Comparative evaluation of experimental data on a-amylase inhibition by flavonoids using molecular modelling Potential risk of furan in foods Comparative study on the toxicity of alternariol and alternariol monomethyl ether in human tumor cells of different origin A role for resveratrol and curcumine in sensitization of glioblastoma cells to genotoxic stress induced by alkylating chemotherapeutics BfR-risk-assessment of alkaloids as ingredients and contaminants of food: quinine, opium alkaloids, senecio pyrrolizidine alkaloids Elucidation of the genotoxic activity of the alkaloid ellipticine in human cell lines Dietary supplements and herbal medicinal products - for a clear differentiation. Statement of the Society for Phytotherapy (GPT) to the "Article 13 Health Claim list" of the EFSA Assessment of genotoxicity of herbal medicinal preparations according to the guideline EMEA/HMPC/107079/2007 - A model project of Kooperation Phytopharmaka, Bonn, Germany Implications for an adverse effect of vitamin C in photodynamic therapy Using the nematode caenorhabditis elegans to identify des mode of action of the flavonoid myricetin Low-Temperature Plasma - Mild preservation technology for minimal processed fresh food? Influence of fumonisin B1 on gene expression and cytokine production Effects of quercetin on the detoxification of the food contaminant benzo[a]pyrene in the human intestinal Caco-2 cell model Risk assessment of T-2 and HT-2 toxin using human cells in primary culture Pyrrolizidine alkaloids in honey bee products Identification of molecular determinants for cytotoxicity of isoliquiritigenin from liquorice (Glycyrrhiza glabra) towards leukemia cell lines Functional effects of polyphenol metabolites produced by colonic microbiota in colon cells Lifelong exposure to isoflavones results in a reduced responsivity of the mammary gland in female rats towards estradiol Derivation of maximum amounts for the addition of functional ingredients to foods Constituents of ginger induce micronuclei in two mammalian cell systems in vitro Relative photomutagenic potency of furocoumarins and limettin Degradation of green tea catechins Evaluation of the cytotoxic effects of herbal homeopathic extracts in primary human hepatocytes in vitro Modulation of antioxidant gene expression by apple juice in rats Predictivity comparison between screening assays for bacterial mutagenicity for natural compounds: micro-ames vs. ames fluctuation method Automated in vitro micronucleus testing of natural compounds in correlation with hydrogen peroxide Permeability of apple polyphenols in T84 cell model and their influence on tight junctions Influence of apple polyphenols on inflammatory gene expression Diethylstilbestrol-like effects of genistein on gene expression of Wnt-signaling components in the endometrial Ishikawa cell line Effect of dietary flavonoids in different cell lines: Comparison of uptake, modulation of oxidative stress and cytotoxic effects Risk-benefit considerations of isoflavone supplements in the treatment of menopausal vasomotor symptoms Effect of different catechins on the growth of HT-29 cells Determination of the isoflavone content of soy-based infant formulas of the German market using a Box-Behnken experimental design for optimising the analytical conditions MEMBERS OF THE DFG SENATE COMMISSION ON FOOD SAFETY PARTICIPANTS AND CONTRIBUTORS OF THE SYMPOSIUM

Informations sur le produit

Titre: Risk Assessment of Phytochemicals in Food
Code EAN: 9783527329298
ISBN: 978-3-527-32929-8
Format: Couverture cartonnée
Editeur: Wiley-VCH
Genre: Chimie
nombre de pages: 476
Poids: 911g
Taille: H240mm x B170mm x T25mm
Année: 2010
Auflage: 1. Auflage