Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics

Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.

Contenu
List of Contents.- Reverse Genetics of Mononegavirales.- Reverse Genetics Systems for the Generation of Segmented Negative-Sense RNA Viruses Entirely from Cloned cDNA.- Transcription and Replication of Nonsegmented Negative-Strand RNA Viruses.- Orthomyxovirus Replication, Transcription, and Polyadenylation.- Escaping from the Cell: Assembly and Budding of Negative-Strand RNA Viruses.- Accessory Genes of the Paramyxoviridae, a Large Family of Nonsegmented Negative-Strand RNA Viruses, as a Focus of Active Investigation by Reverse Genetics.- Identification and Characterization of Viral Antagonists of Type I Interferon in Negative-Strand RNA Viruses.- Toward Novel Vaccines and Therapies Based on Negative-Strand RNA Viruses.- Influenza Vaccines Generated by Reverse Genetics.