Annual Review of Gerontology and Geriatrics

Klappentext Enormous advances in our knowledge of genetic contributions to aging and disease, and in our understanding of the potential for manipulation of the aging process, have taken place during the past 20 years. This is the first volume in decades to consolidate this research in one place. It provides a broad and current overview of the most promising advances in genetic research on aging, current understanding of genetic contributions to the basic processes of aging, and age-related disease. The Review focuses on the aging process from lower organisms to man, and is organized in ascending order of biological complexity starting with stem cells and progressing through worms, flies, mice, and humans. Where relevant, the Review also includes information about yeasts and non-human primates. The research presented in the Review uses a species-comparative approach that makes finding cross species similarities (gene conservation) and differences (gene differentiation) apparent. This approach reflects the way in which the field is organized, making it highly useful for investigators who want quick access and a concise summary of a particular topic. Key Features: Provides state-of-the-art information about promising advances in genetic research on aging Comprises the first comprehensive volume regarding genetic research about aging in decades Authored by leading scholars in the field Disseminates enormous advances in our understanding of the aging process Inhaltsverzeichnis Preface 1. Longevity pathways in mammalian stem cells Anne Brunet, Salah Mahmoudi, Elena Mancini, Victoria A. Rafalski, and Ashley E. Webb 2. Essential Genes and Lifespan Sean P. Curran 3. Oxygen and Aging Jason N. Pitt, Scott F. Leiser, and M. Kaeberlein 4. Aging, Disease and Longevity in Mice David B. Lombard and Richard A. Miller 5. Primate Models for Human Brain Aging and Neurological Diseases Caleb Finch and Steve Austad 6. Genes for Exceptional Longevity Nir Barzilai and Gil Atzmon 7. Etiology of Individual Differences in Human Health and Longevity Deborah Finkel, Lotte Gerritsen, Chandra A. Reynolds, Anna K. Dahl, and Nancy L. Pedersen 8 Exploiting causal complexity in aging Gerald E. McClearn, David J. Vandenbergh, J. Tobias Stout, and Roger J. McCarter 9. Networks in the Biology of Aging: Powerful tools for a complex process Mark A. McCormick and Daniel E. L. Promislow 10. Nature, Nurture & Chance: Their Roles in Interspecific & Intraspecific Modulations of Aging George M. Martin ...

Contenu

Preface

1. Longevity pathways in mammalian stem cells

   Anne Brunet, Salah Mahmoudi, Elena Mancini, Victoria A. Rafalski, and Ashley E. Webb

2. Essential Genes and Lifespan

   Sean P. Curran

3. Oxygen and Aging

   Jason N. Pitt, Scott F. Leiser, and M. Kaeberlein

4. Aging, Disease and Longevity in Mice

   David B. Lombard and Richard A. Miller

5. Primate Models for Human Brain Aging and Neurological Diseases

   Caleb Finch and Steve Austad

6. Genes for Exceptional Longevity

   Nir Barzilai and Gil Atzmon

7. Etiology of Individual Differences in Human Health and Longevity

   Deborah Finkel, Lotte Gerritsen, Chandra A. Reynolds, Anna K. Dahl, and Nancy L. Pedersen

   8 Exploiting causal complexity in aging

   Gerald E. McClearn, David J. Vandenbergh, J. Tobias Stout, and Roger J. McCarter

8. Networks in the Biology of Aging: Powerful tools for a complex process

   Mark A. McCormick and Daniel E. L. Promislow

9. Nature, Nurture & Chance: Their Roles in Interspecific & Intraspecific Modulations of Aging

   George M. Martin